Absorption increased in presence of fatty food. Reduced plasma levels with enyme reducers eg. phenytoin, carbamazepine, Increased plasma levels with cimetidine

Whipworm, pinworm, round, hook worms single or mixed infections.

Transcient diarrhea, Abdominal pain Nausea, headache Tinnitus, numbness, Fever, dizziness, Myelosuppression ( high doses )

Hypersens to benzimidole derivatives.1st trimester of pregnancy,infants & child < 2years Special precautions: Monitor blood counts & hepatic function esp. in patients receiving high doses Pregnancy and lactation

Indications:

Whipworm, pinworm, round, hook worms single or mixed infections.

Dosage:

100mg bid for 3 conscecutive days Alternately 500mg as a single dose. a 2nd course may be given if patient is not cured within 3-4 weeks child- > 1yr 100mg bid for 3 consecutive days alternately, 500mg as a single dose if a patient is not cured within 3-4 weeks

Pharmacology:

Mebendazole inhibits formation of the worms microtubules and irreversibly blocks glucose uptake, therby depleting the endogenous glycogen stored within the parasite.

Pharmacokinetics:

Mebendazole is poorly absorbed. P:eak plasma levels are reached in 2 to 4 hours, folowing administration of 100mg of mebendazole daily for 3 consecutive days.

Not significant

Pregnancy:

Use only if needed during the first trimester of pregnancy, only if the benefits outweigh the potential hazards

Lactation:

Safety for use in the nursing mother has not been established.

Children:

Safety and efficacy for use in children below 2 years of age have not been established.