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Updated On: 27-02-2024

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Praziquantel - @- Anthelmintics- (FDC- List )(March 2010)

Drug Name:
Praziquantel - @- Anthelmintics- (FDC- List )(March 2010)

List Of Brands:

BILTRICIDE *
CYSTICIDE

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Reduced plasma conc. when used with dexamthasone Carbamazepine, phenytoin, and chloroquin may reduce the bioavailability of praziquantrel while cimetidine may increase the bioavailability of praziquantel

Indication:

New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing

(Ref- IDMA Publication)

Name of Drug Indication Date of Approval

Praziquintel 175mg 30-03-2010

+ Pyrantel 504mg

+Febental 535mg tablets

For the treatment of Mixed Infections with Roundworms and Tapeworms

in dogs

FIXED DOSE COMBINATIONS APPROVED BY DCG(I)

FROM JANUARY 1961 TILL NOVEMBER 2014

Name of Drug Indication Date of Approval

1.Praziquantal 20mg+ 25-11-2013

Pyrantel embonate 230mg tablet

Veterinary product

For the treatment of mixed infectations with roundworms

and tapeworms with dogs

2.Praziquantel 175mg + 30-03-2010

Pyrantel 504mg +

Febental 525mg tablets

For the treatment of mixed infections with roundworms

and tapeworms in dogs

Schistosomiasis

Adverse Reaction:

Well tolerated. Occassionally,Malaise, headache, dizziness,abdominal discomfort,, rarely urticaria.

Contra-Indications:

Previous hypersensitivity to praziquantel

Special precautions:

Hazardous tasks- may produce drowsiness, observe caution while driving or performing tasks requiring alertness on the day of and folllowing treatment. Minimal increase in liver enzymes have occured in some patients.

Dosages/ Overdosage Etc:

Indications:

Schistosomiasis

Dosage:

3 doses of 20mg/kg as a 1 day treatment. The interval between the doses should not be less than not more than 6 hours. Swallow the tablets unchewed with some liquid during meals.

Patient Information:

1. Take with liquids during meals. Do not chew tablets

2. May cause dizziness or drowsiness, observe caution while driving or performing

other tasks requiring alertness

Ref - USP PDI Vol II 17th Edition (1997)

PRAZIQUANTEL- Systemic

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

praziquantel. Also tell your healthcare care professional if you are allergic to any

other substances such as foods. preservatives or dyes.

2.Pregnancy-

Studies have not been done in humans. However, studies in rats and rabbits

given up to 40 times the normal human dose have not shown to cause

birth defects. However, praziquantel has shown to cause a greater chance

of miscarriage in rats given 3 times the human dose.

3. Breast-feeding-

Praziquantel passes into breast milk. You should stop breast feeding on the day

you begin praziquantel. Do not restart breast-feeding until 72 hours after treatment

is completed. During this period the breast milk should be squeezed out or

sucked out with a breast pump and thrown away.

4.Children-

This medicine has been tested in a limited number of children 4 years age

or older and in effective dises , has not been reported to cause different

side effects or proplems in children over 4 years of age than it does in adults.

5.Older adults-

There is no specific information comparing use of praziquantel in the elderly

with use in other age groups

6. Other medicines-

Tell your doctor if you are using any of the other prescription or

non-prescription (Over-the counter) OTC medicine.

7. Other medical problems-

Make sure you tell your doctor if you have any other medical problems

especially-

Liver disease- patients with moderate to severe liver disease may have

an increased chance of side effects

Worm cysts in the eye- the death of worm cysts in the eyes caused

by praziquinrel may cause damage to the eyes.

Pharmacology/ Pharmacokinetics:

Pharmacology:

Praziquantel increases cell membrane permeability in susceptible worms, resulting in loss of intracellular calcium, massive contrations and paralysis of their musculature.

Pharmacokinetics:

It is rapidly absorbed (80%) reaching a maximum serum concentration in 1 to 3 hours. It undergoes significant first pass biotransformation, elimination half-life of parent drug is 0.8 to 1.5 hrs ; 4 to 5 hrs for metabolites. Metabolites are excreted primarily in urine.

Interaction with Food:

Can be taken with meals.

Pregnancy and lactation:

Pregnancy:

Use this drug during pregnancy only when needed.

Lactation:

Do not nurse during treatment or the subsequent 72 hrs.

Children:

Safety in children below 4 yrs has not been established

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