Drug Information

Drug Interaction:

Interacting drugs- summary

Factor IX +

Aminocaprioic acid do not co-administer; this may increase the risk of thrombosis.

Indication:

Factor IX defeciency

Adverse Reaction:

Pyrogenic reactions, chills and fever.

Rapid infusion rate- headache, flushing, changes in blood pressure or pulse rate, transient fever, chills, tingling, utcaria may occur.

Contra-Indications:

Treatment of factor VII defiencies, liver disease.

Special precautions::

Perform factor VII assays at least once a day.

Dosages/ Overdosage Etc:

Indication-

Factor IX defeciency

Dosage-

One unit is defined as the activity present in 1ml of average normal fresh plasma. Potency is standarised in terms of factor IX content

Administer by IV injection or drip only

Patient Information:

Ref - USP PDI Vol II 17th Edition (1997)

1.Allergies-

Tell your doctor if you are have ever had any unusual or allergic reaction to Factor IX

injections . Also tell your healthcare care professional if you are allergic to any other

substances such as foods. preservatives or dyes.

2.Pregnancy-

Studies on effects in pregnancy have not been done in humans or animals

3. Breast-feeding-

It is known whether factor IX injections products passes into breast milk. Although most

medicines pass into breast milk in small amounts,many of them may be used safely

while breast-feeding. Mothers who are taking this medicine and who wish to breast feed

should discuss this with their doctor.

4.Children-

Blood clots may be especially likely to occur in premature and new born babies, who are

more sensitive than adults to the effects of injection of factor IX.

5.Older adults-

This medicine has been tested and has not been shown to cause different side effects

or problems in older people than it does in younger adults

6. Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur.

In such cases your doctor may want to change the dose, or other precautions

may be necessary.

Tell your doctor if you are using any other prescription or non-prescription (Over-the counter) OTC medicine.

7. Other medical problems-

The presence of other medical problems may affect the use of factor IX products.

Make sure you tell your doctor if you have any other medical problems

especially-

Liver disease - risk of bleeding or developing clots may be increased

Pregnancy and lactation:

Pregnancy

Give to pregnant women only if clearly needed.

Children-

Demonstrated to be safe and effective in children with hemophilia B

Factor IX coagulation plasma protein -@

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation