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Updated On: 27-02-2024

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Zinc salts @- (FDC- List )

Drug Name:
Zinc salts @- (FDC- List )

List Of Brands:

VERAZINC *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Interacting Drugs - summary

Zinc salts +

Fluroquinolones GI absorption and serum levels of some fluoroquinolones decreased, possibly resulting in a decreased anti-infective response. Avoid simultaneous use,asdminister 2 to 4 hours after the fluoroquinolones

Tetracycline GI absorption and serum levels of tetracyclines decreased, possibly resulting in a decreased anti-infective response. Doxycycline does not appear to be affected

Drug/Food interactions- Bran products (including brown bread) and some foods( eg. protein, phytates, some minerals) may decrease zinc absorption

Indication:

FIXED DOSE COMBINATIONS APPROVED BY DCG(I)

FROM JANUARY 1961 TILL NOVEMBER 2014

Name of Drug Indication Date of Approval

ZnSO4 0.660mg Hepatahydrate eq.to 08-101994

elem. Zn 0.15mg +

CuSO4 0.236mg Pentasulphate eq to

elem Copper 0.06mg +

Chromic chloride 1.83mg anhydrous eq to

elem Chromium 0.6mg +

MnSo4 0.047mg monohydrate eq.to

elem Manganese 0.25mg +

Benzyl alcohol 1% preservative

Trace metal additive infusion (TMA infusion)

Dietary supplement

Interacting Drugs - summary

Zinc salts +

Fluroquinolones decr GI absorption and serum levels of some fluoroquinolones decreased, possibly resulting in a decreased anti-infective response.

Avoid simultaneous use,asdminister 2 to 4 hours after the fluoroquinolones Tetracycline decr GI absorption and serum levels of tetracyclines decreased, possibly resulting in a decreased anti-infective response. Doxycycline does not appear to be affected

Adverse Reaction:

Nausea, vomting

Contra-Indications:

Pregnancy

Special precautions:

Do not exceed the prescribed dosage, will cause emesis if administered in single 2 g doses.

Warnings

Excessive intake- in healthy persons amy be deleterious. Even healthy men who ingested 150mg twice daily for 6 weeks showed significant impairment of lymphocyte and polymorphonuclear leukocyte functions and a significant decrease in high density lipoproteins (HDL)

Pregnancy- since zinc deficiency is very rare, the routine use of zincsupplementation during pregnancy is not recommended. However a dietary zinc intake of 15mg/day is recommended.

Lactation- breast milk concentration of zinc decrease over time following delivery, extra dietary intake of zinc of 7mg/day for the first 6 months of lactation and 4mg/day during the second 6 months are recommended.

Dosages/ Overdosage Etc:

Indications:

Dietary supplement Dosage: Average adult dose is 25 to 50mg zinc daily

Overdosage- Symptoms Nausea, vomiting, dehydration, restlessness sideroblastic anemia (secondary to zinc- induced copper toxicity)

Treatment

1. Reduce dosage or discontinue to continue symptoms

Missed dose

1. If you taking zinc supplements for one or more days threr is no cause for concern, since it takes some time for your body to become low in zinc.

2. However, if your health care professional has recommended that you take zinc, try to remember to take it as directed every day

Patient Information:

If GI upset ocurs ,take with food, but avoid foods high in calcium, phosphorus.

Ref - USP PDI Vol II 17th Edition (1997)

ZINC SUPPLEMENTS - SYSTEMIC

1.Allergies-

Tell your doctor if you are allergic to any other substances such as foods,

preservatives or dyes.

2.Pregnancy-

It is especially important that you are receiving enough vitamins and minerals

when you become pregnant and that you continue to receive the right amount

of vitamins and minerals throughout your pregnancy. The healthy growth and

development of the fetus depend upon a steady supply of nutrients from the

mother.

There is evidence that low blood levels of zinc lead to problems in pregnancy

or defects in the baby. However, taking large amounts of dietary supplements

may be harmful to the mother and/or fetus and should be avoided.

3. Breast-feeding-

It is important that you receive the right amounts of vitamins and minerals

needed for the baby to grow properly. However, taking large amounts of

dietary supplements while breast-feeding may be harmful to the mother

and/or baby and should be avoided.

4.Children-

Problems in children have not been reported with intake of normal daily

recommended amounts.

5.Older adults-

There is some evidence that the elderly may be at risk of becoming

deficient in zinc due to poor selection, decreased absorption of zinc by

the body, or medicines that decrease absorption or increase loss

of zinc from the body.

6. Other medicines-

When you are taking zinc supplements it is especially important that your

doctor know if you are taking any of the following-

Copper supplements or

Tetracycline - use with zinc supplements may cause these copper

supplements or tetracycline to be less effective, zinc supplements

should be given 2 hours after copper supplements or tetracycline

7. Other medical problems-

The presence of other medical problems may affect the use of zinc

supplements. Make sure you tell your doctor if you have any other

medical problems especially-

Copper deficiency - zinc supplements may make the condition worse.

Pharmacology/ Pharmacokinetics:

Pharmacology:

Normal growth and tissue repair depend upon adequate zinc. Zinc acts as an integral part of several enzymes important to protein and carbohydrate metabolism.

Pharmacokinetics:

Zinc salts are poorly absorbed from G I tract; 20 to 30% of dietary zinc is absorbed

Interaction with Food:

Drug/Food interactions- Bran products (including brown bread) and some foods( eg. protein, phytates, some minerals) may decrease zinc absorption

Pregnancy and lactation:

Pregnancy:

Routine use of zinc supplementation during pregnancy is not recommended.

Lactation:

Breast milk concentrations of zinc decreases over time following delivery; extra dietary intake of zinc of 7mg/day for the first 6 months of lactation and 4mg/day during the second 6 months are recommended.

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