Dosages/ Overdosage Etc:
Indication-
Supplement to IV solution given for TPN
Dosage:
Adults- 10 to 15mcg/day Metabolically stable adults- 20mcg/day
Children- 0.14 to 0.2mcg/kg/day Chromium Picolinate Recommended daily dose is 200- 1000mcg
Overdosage- Nausea, vomiting, GI ulcers, renal/hepatic damage, convulsions, coma
Patient Information:
Chromium supplements- Systemic
1.Allergies-
Tell your doctor if you are have ever had any unusual or allergic reaction to
chromium. Also tell your healthcare care professional if you are allergic to
any other substances such as foods. preservatives or dyes.
2.Pregnancy-
It is especially important that you are receiving enough vitamins and minerals
when you become pregnant and that you continue to receive enough vitamins
and minerals when you become pregnant and that you continue to get the right
amount of vitamins and minerals throughout your pregnancy .
The healthy growth and development of the fetus depend on a steady supply
of nutrients from the mother. However, large amounts of dietary supplement
during pregnancy may be harmful to the mother and/or fetus and should be
avoided
3. Breast-feeding-
It is especially important that you receive the right amount of vitamins and
minerals so that your baby will also get the vitamins and minerals needed
to grow properly. However, taking large amounts of dietary supplement
may be harmful to the mother and/or baby and should be avoided
4.Children-
Problems in children have not been reported with intake of normal daily
recommended amounts
5.Older adults-
Problems in older adults have not been reported with intake of normal daily
recommended amounts
6. Other medicines-
Although certain medicines should not be used together at all, in other cases two
different medicines may be used together even if an interaction might occur.
In such cases your doctor may want to change the dose, or other precautions
may be necessary.
Tell your doctor if you are using any other prescription or non-prescription
(Over-the counter) OTC medicine.
7. Other medical problems-
The presence of other medical problems may affect the use of chromium.
Make sure you tell your doctor if you have any other medical problems
especially-
Diabetes mellitus (sugar diabetes) - taking chromium supplements when
you have a chromium deficiency may cause a change in the amount
of insulin you need.
Pharmacology/ Pharmacokinetics:
Pharmacology:
The human body secretes the hormone insulin. The primary function of insulin is to convert glucose into glycogen. Chromium is considered an essential trace nutrient. Cr binding protein a naturally occuring oligopeptide, low molecular weight chromium binding substance(LMWCr) has been found to activate insulin receptor kinase activity up to 7 fold. This activation may lead to increased insulin sensitivity
Pharmacokinetics:
After oral administration of chromium picolinate supplement at 40mcg Cr/day for 3 days to male and female volunteers, the mean percentage of Cr absorbed was 2.8% with a range of 1.5 -5.2%. Half of the dose is retained in the liver. It is slowly excreted from cells and tissues and therefore, increased absorption of Cr may lead to accumulation of chromium.
