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Updated On: 18-11-2024

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Etidronate disodium- @ -Bisphonates

Drug Name:
Etidronate disodium- @ -Bisphonates

List Of Brands:

DRONATE -OS

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

Drug Interaction:

Bisphonates include- Alendronate, Etidronate, Pamidronate
Refer Alendronate

Warfarin, calcium, aluminium or manesium containg antacids

Indication:

Pagets disease of the bone

Bisphonates include- Alendronate, Etidronate, Pamidronate

Refer Alendronate

Approved by (DCI) Drug Controller GENERAL - India For Marketing

(Ref- IDMA Publication)

Name of Drug Indication Date of Approval

Etidronate Disodium Anti-cancer March 1995

Adverse Reaction:

Diarrhoea, nausea, angioedema, urticaria, rash and pruritus. Pagets disease- increased or
recurrent bone pain at pagetic sites. Hypercalcemia of malignancy.

Contra-Indications:

Hypersensitivity to biphosphonates.

Special precautions::
Pagets disease- Response to therapy may be slow and may continue for months after
treatment has been discontinued. Do not increase dosage before there is evidence of
reactivation of the disease process. Do not initiate retreatment until the patient has had at
least a 90 days drug-free interval.

Renal effects- Occasional mild to moderate abnormalities in renal function have been
observed.Carcinogenesis,impairment of fertility.
Pregnancy and lactation.- excercise caution
Children- safety and efficacy not established.

Dosages/ Overdosage Etc:

Indications:
Hypercalcemia
Pagets disease of the bone

Dosage:
Recommended dose is 7.5mg/kg/day for 3 successive days. The daily dose must
be diluted in at least 250ml of sterile normal saline.
Storage:
The diluted solution is stored at controlled room temperature(15 to 30C). shows no drug
loss for 48 hours..

Patient Information:

Ref - USP PDI Vol II 17th Edition (1997)

1.Allergies-

Tell your doctor if you are have ever had any unusual or allergic reaction to

etidronate. Also tell your healthcare care professional if you are allergic to any other

substances such as foods. preservatives or dyes.

2.Diet-

Make certain that your doctor knows that knows if your diet includes large amounts of

calcium, such as diary products or if your are any special diet such as low -sodium

or low sugar diet. Calcium in the diet may prevent the aborption of oral etidronate.

3.Pregnancy-

Studies have not been done in humans. However, studies in rats injected in

large doses of etodronate has shown that etidronate causes deformed bones

in the fetus.

4. Breast-feeding-

It is known whether etidronate passes into breast milk. However, this medicine

has not been reported to cause problems in nursing babies.

5.Children-

Some changes in bone growth may occur in children, but will usually go away

when the medicine is stopped.

5.Older adults-

When etidronate is given by injection along with large amount of fluids ,older

people tend to retain the excess fluid.

6. Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur.

In such cases your doctor may want to change the dose, or other precautions

may be necessary.

Antacids containing calcium ,magnesium or aluminium or

mineral supplements or other medicines containing calcium, magnesium or

- these will decrease the effects of etidronate

7. Other medical problems-

The presence of other medical problems may affect the use of etidronate..

Make sure you tell your doctor if you have any other medical problems

especially-

Bone fracture , especially arm or leg- etidronate may increase the risk of

fracture.

Intestinal bowel disease- etidronate may increase the risk of diarrhea

Kidney disease- high blood levels of etidronate may result causing

serious side effects

Pregnancy and lactation:

Pregnancy and lactation.
Excercise caution

Children-
Safety and efficacy not established.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.