CETROTIDE INJ
Manufacturer Details
SERUM INSTITUTE
Compositions:
Cetrorelix 0.25mg/ml injection,
|
Strength
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Rate
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Packing Style
|
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0.25mg/ml
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2272.00
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1 vial injection
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List of Related Indications:
- Prevention of premature ovulation
List Of Drugs:
- Cetrorelix- Ovulation Stimulant - Sex Hormone
Indication Type Description:
Pharmacology/ Pharmacokinetics
Indication:
Prevention of premature ovulation in controlled ovarian stimulation followed by oocyte pick-up and assisted reproductive techniques
Adverse Reaction:
Injection site reactions Ovarian hyperstimulation syndrome Headache, nausea Elevated enzyme e.g. ALT , alkaline phosphatase
Contra-Indications:
Moderate to severe renal or hepatic imapirment Post menopause Pregnancy Lactation Extrinsic pedptide hormone Mannitol hypersensitivity
Special pecautions- Repeated ovarian stimulation oe cycles, Active allergic conditions Do not complete gynaecolgical and endocrinal exam first
Dosages/ Overdosage Etc:
Prevention of premature ovulation in controlled ovarian stimulation followed by oocyte pick-up and assisted reproductive techniques 0.25mg once daily by s.c injection into lower abdomen wall given within 96 -120 hours of starting ovarian stimulation with gonodotrophin . Continue upto and inculding day of ovulation injection Alternatively a single s.c. inj on day 7 of ovarian stimulation If ovarian induction is not possible on the 5th day after injection aditionaly inject 0.25mg once daily until day of ovulation
Pharmacology/ Pharmacokinetics:
Ref- Drug Facts And comparisons(2010)
Pharmacology-
GnRH induces the production and release of LH and follicle -stimulating Hormone(FSH)
from the gonadotrophic cells at the anterior pitutary. Because of positive estradiol E2
feedback at midcycle, GnRH liberation is enhanced , resulting in LH surge. The LH surge
induces the ovulation of the dominant follicle , resumption of oocyte meiosis and
subsequently luteinization , as indicated by rising progesterone levels
Pharmacokinetics-
The pharmacokinetics of parameters of single and multiple doses of cetorelix in adult
healthy women are summarized in the following table-
Pharmacokinetic Parameters of Cetrorelix Following 3mg Single or 0.25mg
Single and Multiple (Daily for 14 Days) Subcutaneous Administration
Parameter Single Dose Single dose Multiple Dose
3mg 0.25mg 0.25mg
(n=12) (n=12) (n=12)
Tmax 1.5 1 1
(h) (0.5 to 2) (0.5 to 1.5) (0.5 to 2)
T 1/2 62.8 5 20.6
(h) (38.2 to 108) (2.4 to 48.8) (4.1 to 179.3)
Cmax (ng/mL) 28.5 4.97 6.42
(22.5to 36.2) (4.17 to 5.92) (5.18 to 7.96)
CL
(ml/min*kg) 1.28
Vz 1.16
(l/kg)
Pregnancy and lactation:
Observe caution. Contraindicated for use during pregnancy and lactation
