Antihistamines Include:

First Generation ( Non-selective ) Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine.

Ethylenediamines- Pyrilamine, Triplennamine

Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine

 Phenothiazines- Methidilazine, Promethizine, trimeprazine

Piperidines- Azatadine, Cyproheptadine, Phenindamine

Miscellaneous- Astemazole, Loratadine, Terfenadine

Second Generation ( Peripherally selective )

Phthalazinone - Azelastine

Piperazine - Cetrizine

Refer - Chlorpheniramine maleate

Allergic conditions

Antihistamines Include:

First Generation ( Non-selective ) Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine.

Ethylenediamines- Pyrilamine, Triplennamine

Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine

 Phenothiazines- Methidilazine, Promethizine, trimeprazine

Piperidines- Azatadine, Cyproheptadine, Phenindamine

Miscellaneous- Astemazole, Loratadine, Terfenadine

Second Generation ( Peripherally selective )

Phthalazinone - Azelastine

Piperazine - Cetrizine

Refer - Chlorpheniramine maleate

None when taken in therapeutic doses.

Drowsiness, excitability in children.

Asthma, glaucoma, emphysema, chronic pulmonary disease, shortness of breath, difficulty in breathing, BPH.

Special precautions:

Tasks requiring mental alertness, concurrent alcohol, sedatives, tranquilisers, children, pregnancy and lactation.

Indications:

Allergic conditions

Dosage:

Adults and children over 12 years- 1.34mg twice daily to 2.68mg 3 times daily.

Do not exceed 8.04mg per day.

Refer - Chlorpheniramine maleate

1. Inform patients of a history of glaucoma, peptic ulcer, urinary retention, or pregnancy before starting antihistamine therapy

2. May cause nervousness, insomnia, and dry mouth

3. May cause drowsiness, or dizziness(except astemazole,loratadine, and tefenadine)

4. Patients should observe caution while driving or performing other tasks requiring alertness, coordination or physical dexterity.

5. Avoid alcohol and other CNS depressants (eg,. sedatives, hypnotics, tranquilizers)

6. May cause GI upset, take with food. Take Astemazole on an empty stomach, at least 2 hours after or 1 hour before a meal. Take Lorantidine on an empty stomach.

7. Avoid prolonged exposure to sunlight, may cause photosentivity.

8. Do not crush or chew sustained releae preparations

9.Astemazole/ Terfenadine: Patients should not take these agents if they have hepatic dysfunction or if they are also receiving ketoconazole, itraconazole or erythromycin

10. Phenothiazines- Patients should report any involuntary muscle movements or unusual sensitivity to sunlight.

Refer antihistamines

May be taken with meals to reduce GI discomfort

Refer antihistamines