Levodopa 100mg+ Carbidopa 10mg tablets, Levodopa 100mg+ Carbidopa 25mg tablets, Levodopa 25mg+ Carbidopa 25mg tablets,
List of Related Indications:
List Of Drugs:
- Levodopa + Carbidopa- Antiparkinson agents-(2008)
Indication Type Description:
Dosages/ Overdosage Etc
Pregnancy and lactation
Pyridoxine reverses effect of levodopa. Type B MAOIs have synergistic effect. Effects reduced by phenothiazines, haloperidol, reserpine, puridoxine, diazepam, oxazepam, Chlordiazepoxide , phenobarbitone.
Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine Effects of sympathemimetic agents enhanced. Enhances effects of bethanidine, bretylium, guanithidine, Hypertensive crises with furazoidones or MAOI nhibitors
Nausea, vomiting, Anorexia, increased risk of GI bleeding in peptic ulcer patients. Orthostatic hypotension, cardiac arrhthmias, Pschiatric symptoms ( depression with or without suicidal tendecy ) Abnormal involuntary movements or dyskinesias, Delirium, hallucinations ( elderly ) Slight elevation in liver enzymes, Leucopenia, thrombocytopenia. Severe hypotension in elderly
Hypersens, concomittant therapy with MAO inhibitors, narrow angle glaucoma, suspicious undiagnosed skin lesions, history of melanoma, lactation.
In patients receiving levodopa drug must be discontinued atleast 8 hr prior to starting combination. History of depression, suicidal tendencies, severe CVS or pulmonary disease, bronchial asthma, renal hepatic or endocrine disease, myocardial infarction, arrhythmias, peptic ulcers, withdraw drug gradually, pregnancy. Regular monitoring of renal and hepatic function is recommended
Dosages/ Overdosage Etc:
Adult- initially - 1 tab tid, increase by 1 tablet a day every 1-2 days up to a max of 8 tablet of day If the patient has been taking L-dopa alone, the combination should be started after a gap of at least 8 hr after stopping L-dopa
Pregnancy and lactation:
Observe caution if required to be used pregnancy and lactation