ORGARAN*
Brand:
ORGARAN*
Manufacturer:
MSD INC
Manufacturer Details
MSD INC
Compositions:
Danaparoid Sodium 1250 units/ml 0.6ml amp.injection,
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Strength
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Rate
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Packing Style
|
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1250units/ml
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0.00
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0.6ml amp. jnjection
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List of Related Indications:
List Of Drugs:
- Danaparoid Sodium- Anti-coagulant- (BNF 68 - 2015)
Indication Type Description:
Indication:
Heparin induced thrombocytopenia
Adverse Reaction:
Side effects-
Bleeding, hypersensitivity reactions (including rash)
Contra-Indications:
Cautions-
Recent bleeding or risk of bleeding, Concomittant use of drugs that increase
risk of bleeding, antibodies to heparins (risk of anti0body induced
thrombocytopenia), body weight over 90kg ( monitor anti factor- Xa activity)
Contra-indications-
Hemophilia and other haemorrhagic disorders, thrombocytopenia)
unless patient has heparin induced thrombocytopenia)
recent cerebralhaemorrhage, severe hypertension, active peptic ulcer
(unless this is is reason for operation) diabetic retiniopathy,
acute bacterial endocarditis, spinal or epidural anaethesia with
treatment of danaparoid
Hepatic Impairment-
Caution in moderate impairment (increased risk of bleeding)
avoid in severe impairment unless patient has heparin- induced
thrombocytopenia and no alernative available
Renal impairment-
Caution in moderate impairment, increased risk of bleeding
(monitor anti-Factor Xa activity), avoid in severe impairment
unless patient has heparin-induced thrombocytopenia and
no alternative available.
Dosages/ Overdosage Etc:
Indication-
Prevention of deep vein thrombosis
Dose-
Prevention of deep vein thrombosis,
by subcutaneous injection
750 units twice daily for 7-10 days
initial treatment before operation
(with last preoperative dose 1-4 hiurs before surgery)
Thromboembolic disease in patients with a history of
heparin-induced thrombocytopenia
by intravenous injection
2500 units (1250 units of body weight under 55 kg
3750 units if over 90kg
followed by intravenous infusion of
400 units for 2 hours then
300units/hour for 2 hours,then
200units /hour for 5 days
Pregnancy and lactation:
Pregnancy-
Manufacturer advices avoid- limited information available
Breast feeding-
Amount probably too small to be harmful but manufacturer
advices avoid.
