Mercaptopurine 50mg tablets,
List of Related Indications:
- Acute leukaemia
List Of Drugs:
- Mercaptopurine -@- Antimetabolites-(Apr 2014)
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Interacting drugs- summary -
Allopurinol when administered concomittantly with mercaptopurine , reduce the mercaptopurine to 1/3 to 1/4 the usual dose . Failure to observe dosage reduction will delay catabolosim of mercaptopurine and increase likelihood of severe toxiicity
Trimethoprin-sulfomethoxazole when coadmin with mercaptopurine enhanced marrow suppression has occurred
Myleosupression. Hyperuricaemia, bone marrow toxicity, Anorexia,diarrhoea, leucopenia, Thrombocytoenia, Hepatic injury, jaundice, Intestinal ulceration, Immunosupression, Intestinal pneumonitis.
Hepatic or renal dysfunction. Use only specialists direction. Support facilities must be available in case of bone marrow aplasia.
The drug is potentially mutagenic, teratogenic and carcinogenic.
Dosages/ Overdosage Etc:
Acute lympatic leukemia.
Individualise dose. Usual dose - 2.5mg/kg/day( 100 to 2OOmg for average
Adult and 50mg for average 5 years old).
Continue daily for several weeks or more.
Mercaptopurine (6-MP) competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase and is converted to thionosinic acid(TIMP). This intracellular nucleotide inhibits several reactions involving inosinic acid(IMP).
The absorption of oral mercaptopurine is complete.
Interaction with Food:
Pregnancy and lactation:
Refer methotrexate- antimetabolites