Not reported

Peripheral sensory neutropathy      Pharyngo-laryngeal dyasthesia       anemia including imuno-haemolytic anemia     

 Neutropenia ,thrombocytopenia     Nausea, diarrhea   Muscositis/stomatitis      Alopecia

Raised liver enzymes       Allergic reactions      Fever Ototoxicity    Rash Arthalgia     Back pain, colitis

Renal function disturbances         tempororary loss of visual acuity   

 intestinal lung disease ( sometimes fatal )

Severe renal impairment        Neutropaenia        Thrombocytoma       Peripheal sensory neuropathy Myelosuppression Pregnancy Lactation

Special precautions

Moderate renal impairment      Monitor renal function   

History of sensitivity to platinum compds      Monitor for allergic reactions

Discontinue immediately if anaphyloid reactions occur and do not rechallenge

Perfrom neurological eaxm, before each dose

Discontinue or reduce dose if parathesia or dysaethesia are present

Peform full blood count and white cell differntial before each dose

Discontinue if unexplained respiratory symptoms occur

Indication-

Metastatic colorectal cancer

Dosage-

85mg/m2 every two weeks by iv infusion over 2-6 hrs prior to admin of 5FTU

Use contraindicated. Observe caution