ROSUKEM-F
Brand:
ROSUKEM-F
Manufacturer:
ALKEM
Manufacturer Details
ALKEM
Alkem laboratories Ltd.
Dev Asish Bldg,Near Mautulya Centre
Senapati Bapat Marg,
Lower Parel
Mumbai 400013
Compositions:
Rosuvastatin 10mg + Fenofibrate 160mg tablets,
|
Strength
|
Rate
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Packing Style
|
|
10mg+ 160mg
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169.00
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10s tablets
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List of Related Indications:
List Of Drugs:
- Rosuvastatin + Fenofibrate
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Reports not available
Indication:
Hyperlipidemia and mixed dyslipidemia
Adverse Reaction:
Myopathy, hepatotoxicity and renal damage
Contra-Indications:
Hypersenstivity to any of the ingredients
Dosages/ Overdosage Etc:
Hyperlipidemia and mixed dyslipidemia
Dosage-
one tablet daily
Pharmacology/ Pharmacokinetics:
Pharmacology
Rosuvastatin is a reversible competitive inhibitor of HMGCoA Reductase which prevents or controls the conversion of 30hydroxy-3 -methylglutaryl coenzyme A to mevalonate , a precursor for chloesterol
Rationale for combination- rosuvastatin significantly decreases serum TGs , total cholestrol , LDL-C , non -HDL cholesterol and apoliproprotein B ApoB levels. Fenobibrate a fibric acid derivative is used as anti-hyperlipedemic agent due to the lipid modifying property.
Thus the combination of rosuvastatin and fenofibrate gives the synergistic action in reducing LDL-C and increasing HDL- cholesterol levels
