SPIROMIDE
Manufacturer Details
RPG LIFE
Compositions:
Frusemide 20mg+ Spironolactone 50mg tablets,
Spironlactone 50mg,
|
Strength
|
Rate
|
Packing Style
|
|
20mg+50mg
|
55.70
|
10s tablets
|
List of Related Indications:
- Cirrhosis of liver
- Mild to moderate hypertension
- Nephrotic syndrome
- Oedema associated with CHF
List Of Drugs:
- Furosemide + Spironolactone - Diuretics Combination
Indication Type Description:
Drug Interaction:
Potassium supplements or potassium rich diet,ACE inhibitors,general anaesthetics(reduced
vascular responsiveness to catecholamines),lithium.
Aminoglycosides and ethacrynic acid(increased ototoxicity), tubocurazine,succinylcholine
(effects enhanced).
Sucralfate reduces effects of frusemide.Should be given 2 hour apart.
NSAIDs reduce natriuretic and antihypertensive effects of frusemide .
Corticosteroids may antagonise action.
Digoxin levels may be increased.
Warfarin effects may be reduced.
Indication:
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Spironolactone 25mg 05-03-2010
+ Furasimide 700mg tablets
For the treatment of Resistent Odema associated with secondary
Hyperaldosteronism, Resistent Hypertension, Chronic cardiac Failure
and Hepatic Cirrhosis
2.Spironolactone 25mg 05-01-2011
+ Furosimide 40mg tablet
Addl.Stgth
As approved
Refractory edema Hypertension associated with secondary hyperaldeosterronism
Adverse Reaction:
Severe hyperkalaemia in patients with pre-existing renal impairment or taking
ACE inhibitors, agranulocytosis, cardiac arrhythmias.
Fluid and electrolyte imbalance, nausea, diarrhoea, blurred vision, headache, dizziness,
hypotension, photosensitisation hepatic dysfunction, hyperglycaemia and glycosuria,
rarely bone marrow depression, gynaecomastia, hirsutism, hoarseness, menstrual irregularities,
loss of libido,impotence.
Contra-Indications:
History of hypersensitivity, anuria or severe oliguria, hypovolaemia, hyponatraemia, hypotension,
urinary retention due to prostatic hypertrophy. Addison's disease, lactation, renal impairment,
hyperkalaemia, acute or severe liver failure.
Special Precaution:
Concomittant use with ACE inhibitors, monitor fluids and electrolytes including changes in serum
potassium levels, dilutional hyponatraemia or even a true low-salt syndrome may develop.
General anaethesia, pregnancy, lactation.
Dosages/ Overdosage Etc:
Indication-
Refractory edema Hypertension associated with secondary hyperaldeosterronism
Dosage-
1- 4 tabs daily. Adjust dose after 10 days epending on response
Children- not recommended
