Clarithromycin 250mg/500mg tablets,
List of Related Indications:
- Respiratory tract infection
List Of Drugs:
- Clarithromycin ( *** ) - @ Macrolide antibiotic (Oct 1991)
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Drug interactions- summary
incr effects of anticoagulants potentiated,monitor PT Antihitamines incr following coadministration, plasma levels of the active metabolite of terfenadine were threefold higher on average. Do not use concurrently in patients who have preexisting cardiac abnormalities or electrolyte disturbances
increased concentrations of carbamazepine occur Consider monitoring carbamazepine levels
serious cardiac arrhythmias(some fatal) including ventricular tachycardia, ventricular fibrillation, torsade de pointes and QT prolongation have been reported in patients taking cisapride with other drugs that inhibit cytochrome P 450 IIIA4. Concurrent use is contraindicated
elevated cyclosporine with increased risk of toxicity (nephrotoxicity, neurotoxicity) occur
serum digoxin levels elevated
acute ergot toxicity characterised by severe peripheral vasospasm and dyesthesia has occured
Fluconazole + Clarithromycin
concomittant fluconazole led to increase in mean steady state clarithromycin
Clarithromycin + Tacrolimus
plasma tracolimus levels may be increased incresing the risk of toxicity
Clarithromycin + Theophyllines
concurrent use associated with increased serum theophylline.Consider monitoring theophylline levels
CNS effects(eg. somnolence, confusion) have occurred
simultaneous use in HIV- infested patients resulted in decreased steady-state zidovudine levels. Peak serum zidovudine conc. increased or decreased
Hypersensensitivity to Clarithromycin,erythromycin or anyof the macrolide antibiotics.
Pseudomembranous colitis has occurred with nearly all antibacterial agents and may range in severity to mild to life threatening.
It is important to consider this diagnosis in patients who present with diarrhoea susequent to administration of antibacterial agents.
Hepatic/renal function impairment, elderly, pregnancy.
Dosages/ Overdosage Etc:
Clarithromycin was approved by the FDA in October 1991.
Adults- 500mg twice daily
Children- 7.5mg/kg twice daily up to 500mg twice daily.
Clarithromycin may be given without regard to meals and can be taken with milk
. 1. Allergies- Tell your doctor if you have ever had any unusual or allergic raections to clarithromycin or other related medicines. Also tell your doctor if younare allergic to to any other substances suchas foods, precervatives or dyes.
2. Pregnancy- make sure your doctor knows if you are pregnant or if you become pregnant.
3. Breast feeding- clarithromycin passes intop breast milk.
4. Children- this medicine has not beenshown to cause different side effects or problems in children over the age of 6 months than it does in adults.
5. Elderly- elderly patients has not ben shown to cause different side effects or problems tthan in younger adults.
6. Other medicines- tell your doctor if you are taking any other medicines- Carbamazepine or Digitoxin or Terfenadine or Theophylline or Warfarin - clarithromycin may increase the chance of side effects of these medicines.
7. Other medical problems- tell your doctor if you have any other medical problems- Kidney disease- patients with severe kidney disease may have an increased chance of side effects.
8. Missed dose- If you miss a dosew of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double doses.
Interaction with Food:
Clarithromycin can administered without regards for meals
Pregnancy and lactation:
Has adverse effects on pregnancy. Do not use Clarithromycin in pregnant women.
Excreted in breast milk. Excercise caution when administering to a nursing woman
Safety and efficacy in children less than 6 months have not been established