ALTHROCIN


Brand:
ALTHROCIN

Manufacturer:
ALEMBIC CHEMICAL WORKS Co.LTD

  
Compositions:
Erythromycin estolate 250mg/500mg tablets, Erythromucin estolate 250mg d.t- ALTHROCIN- DT, Eryhtromycin estolate 125mg Kid tab- KIDTAB, Erythromucin estolate 100mg chew tab- CHEWABLE TABS, Erythromycin estolate 125mg per 5ml liqd- LIQUID,
  
Strength Rate Packing Style
250mg 36.00 10s tablets
500mg 70.10 10s tablets
250mg d.t 21.30 10s tablets
125mg kId tab 27.90 10s Kidtab
100mg chew tab 17.41 10s Chew tab- Chewable tab
125mg per 5ml 45.20 60ml liquid- Liquid

List of Related Indications:
  • Acute bacterial pharyngitis
  • Amoebic dysentry
  • Bronchitis
  • Carbuncle
  • Carditis
  • Cellulitis
  • Cough Whoopng
  • Epiglottitis
  • Erysipelas
  • Glomerulonephritis
  • Laryngotracheitis
  • Listeriasis
  • Mastoiditis
  • Otitis
  • Pneumonia
  • Pyoderma
  • Sinusitis
  • Tonsilitis

List Of Drugs:
  • Erythromycin ( *** ) @ - Macrolide- (FDC- List ) (Mar 1974)

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

Macrolide antibiotics include- Azithromycibn. clarithromycin, dirithromycin, erythromycin and troleandomycin
Refer-  Erythromycin


Interacting drugs - summary

Erthyromycin  +

Alfentanil
 alfentanil clearance decreased and its elimination half-life increased

Anticoagulants
 anticoagulant effect of warfarin or anisindione  increased.
 The risk of bleeding is increased.

Antihistamines/Astemazole/Terfenadin
  astemazole and terfenadine plasma levels increased, which lead to serious
  cardivascular advere effects

Bromocriptine 
  serum bromocriptine levels increased, resulting in an increase in
  pharmacologic and toxic effects.

Carbamzepine
  carbamazepine toxicity sufficient to require hospitalisation result.
                               
Cyclosporine
  increased Cyclosporine concentrations with renal toxicity occur

Digoxin
 increased serum Digoxin level occur in  a small population of 
  patients(about 10%)  toxic effects occur

Disopyramide
  increased disopyramide plasma level occur. Arrhythmias  and
 increased QTC   have occurred

Ergot alkaloids 
 acute ergotism manifested as peripheral ischemia has occurred

Lincosamide
 under some conditions , coadministration  antagonistic

Macrolide  Antibiotics + Methyl prednisolone
  methylprednisolone clearance decreased

Penicillins 
  In vitro tests and clinical studies demonstrated both                     
   antagonism and synergism with coadministration.

Theophylline
  increased Theophyline serum levels with toxicity are possible.
  Decreased  erythromycin levels  occur

Triazolam  
  Triazolam bioavailability increased, resulting in CNS depression

Lovastatin 
   severe myopathy or rhabdomyolysis occur with concurrent administration

Cisapride 
   in vitro indicate that troleandomycin, erythromycin and clarithromycin
   markedly  inhibit cytochrome p450 IIIA,mainly responsible for
   metabolism of cisapride.
   Concurrent use is contraindicated  

Vinblastine  
   cause toxicity of vinblastine. Severe myalgia, neutripenia and 
   constipation      

Tacrolimus
  these agents increase tacrolimus blood levels