Indication:
LIST OF DRUGS DURING 2007
Sr.No- 160
Name of the Drug- Mupirocin 2% +
Methylprednisolone Acetonate (0.2%) cream Pharmacological Classification- For atopic dermatitis
Date of Approval- 31-10-07
Approved by U.S.FDA on 30-12-2007 (Ref- FDA approved List- 2007)
Eradication of nasal colonisation with staphy aures
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Mupirocin September 1991
Anti- bacterial skin infection
2.Mupirocin 2% 31-010-200
+Methylprednisolone acetonate
0.1% creram
For atopic dermatitis
Adverse Reaction:
Burning, stinging, pain, itching, erythema, dryness, tenderness,
Rarely contact dermatitis and rash.
Contra-Indications:
Hypersens.to mupirocin or ployethylene glycol
Special precauitions:
Mucosal surfaces of the eye, renal impairment( with polythene glycol), pregnancy, lactation.
Dosages/ Overdosage Etc:
Indications:
Eradication of nasal colonisation with staphy aures
Dosage:
Apply small amount of affected area 3 times a day.
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
mupirocin. Also tell your healthcare care professional if you are allergic
to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Toipcal mucirocin has not been studied in pregnant women. However,
this medicine has not been shown to cause birth defects or other problems
in animal studies
3. Breast-feeding-
It is known whether topical mucpirocin passes into breast milk. However, this
medicine is unlikely to pass into breast milk in large amounts.
since very little is absorbed into mothers body when applied to the skin.
4.Children-
There is no specific information comparing use of topical mupirocin
in children with use in other age groups.
5.Older adults-
There is no specific information comparing use of topical mupirocin
in the elderly with use in other age groups
6. Other medicines-
Tell your doctor if you are using any or /other prescription or
non-prescription (Over-the counter) OTC medicine that is
applied to the same area of skin.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Mupirocin , a topical antibacterial structurally unrelated to other agents, is produced by fermentation of the organism pseudomononas fluorescens. Mupirocin inhibits bacterial protein synthesis by reversibly and specicifically binding to bacterial isoleucyl transfer-RNA syntheesis.
Manufacturer Details