No significant interactions reported.

Lepramatous leprosy

Red-brownish black discolouration of skin lesions and skin exposed to sunlight, hair, sweat, sputum, urine, faeces.

Rash, pruritus, photosensitivity. Transient nausea, giddiness,

Mild diarrhoea, abdominal discomfort,

Pain, vomiting, weight loss,

Headache, drowsiness,

Taste disoders,

Dryness of the skin, Ichthysis,

decreased tear and sweat production Crystal depletion

Hypersenstivity- .lactation

Special precautions:

Pregnancy

Patients with GI symptoms

Indications:

Lepramatous leprosy

Dosage:

Take with meals.

Give 100mg/day in combination with one or more antileprosy agents..

1. Take with meals.

2.Clofazine may discolour the skin ,from red to brownish black, as well as discoloring the conjuntivae, lacrimal fluid, sweat, sputum, urine and feces. Skin discolouration although reversible may take several months or years to disappear after the conclusion of therapy.

3. Allergies- Tell your doctor if you have ever had any unusual or allergic raections to clofazimine or other related medicines. Also tell your doctor if youn are allergic to any other substances such as foods, precervatives or dyes.

4. Pregnancy- before you take clofazimine make sure that your doctor knows if you are pregnant or if you become pregnant 5. Breast feeding- clofazimne is not recommended in nursing mothers.

6. Children- no specific information available comparing use in children with use in other age groups. in adults.

7. Elderly- no specific information comparing clindamycin in the elderly with use in other age groups

8. Other medicines- tell your doctor if you are taking  any other prescription or nonprescription ( OTC ) medicines

9. Other medical problems- tell your doctor if you have anyother medical problems- Liver disease - clofazimine may on rare occassion cause hepatitis and liver disease Stomach or intestinal disease- clofazimine may cause stomach upset, but on rare occassion may cause severe sharp abdominal pain and burning wehich may be a sign of a serious side effect. chance of side effects.

10. Missed dose- If you miss a dose of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double doses.

Pharmacology:

Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae. It inhibits mycobacterial growth and binds preferably to mycobacterrial DNA.

Pharmacokinetics:

Absorption rate ranges from 45 to 62% after oral admin. After ingestion of a single 300mg dose, elimination of unchanged drug and its metabolite in urine in 24 hours is negligable. Half-life after repeated doses is estimated to be at least 70days.

Take with food

Pregnancy:

Clofazamine crosses the human placenta. Use during pregnancy only if clearly needed.

Lactation:

Do not administer to a nursing woman.

Children:

Safety and efficacy have not been established