Alcohol- acute ingestion may result in decreased clearance of meprobamate through inhibition of hepatic metabolic systems;
enhanced CNS depressant effects may occur.

CNS depressants- (barbiturates,narcotics) additive CNS depressant effects.  

 

Management of anxiety disorders or short term relief of symptoms of anxiety.

Drowsiness,ataxia,dizziness,slurred speech,
headache,vertigo,weakness,
impairment of visual accomodation,
euphoria,overstimulation,paradoxical excitement,fast ECG activity.

Nausea,vomitting,diarrhoea.
Palpitations,tachycardia,various arrhythmias,
transcient ECG changes,
syncope and hypertensive crises.

 

Acute intermittant porphyria,allergic or idiosyncrati reactions to meprobamate or related
compounds(eg. carisopodil).

Special precautions:
Epilepsy -may precipitate seizures in epileptic patients May produce drowsiness,dizziness or
blurred vision. Caution while performing hazardous tasks or  requiring alertness.


 

Indications:
Management of anxiety disorders or short term relief of symptoms of anxiety.

Dosage:
Adults: 1.2 to 1.6g/day in 3 or 4 divided doses.. Do not exceed 2.4g/day.
Sustained release- 400 to 800mg in the morning and at bed time.
Children- 100 to 200mg 2 or 3 times daily.
Sustained release- 200mg in the mornin and bed time.

 

MEPROBAMATE-

1.Advise patients that if they pregnant during therapy or intend to become pregnant,they should
  consult with their about the use of this drug.
2.May cause drowsinees or blurred vision, use caution while driving or performing other tasks
   requiring alertness.
3.Avoid alcohol or CNS depressant while taking the drug.

4. Allergies-
    Tell your doctor if you had any unusual or allergic reactions to meprobamate
    Tell your doctor if you are allergic to any other substances such as foods, or drinks.

5. Pregnancy-
    Meprobamate  has been reported to increase  the chance of birth defects if taken  during the first
    3months of  pregnancy   

6. Breast feeding-
    Meprobamate  passes into breast milk  and may cause drowsiness in babies of mothers  taking
    this medicine.

7. Children-
    Studies on this medicine  have been done only on  adult patients and there is no specific  information
    comparing use of meprobamate with use  in other age groups

8. Elderly-
     Are more sensitive  to the effects of  meprobamate.This may increase  the chance of side effects
     during treatment

9. Other medicines- Tell your doctor if you are taking any of the following medicines-
 
    Central nervous system depressants  or      
    Tricyclic  antidepressants  - taking  these medicines together  with meprobamate  may increase
     the CNS depressant effects
      
      
10. Other medical problems- Tell your doctor if you have any other medical problems-

      Alcohol abuse or
      Drug abuse or depedence - dependence on meprobamate may develop     
     
       Epilepsy - risk of  seizures may be increased      
       Kidney or
       Liver disease- higher blood levels of meprobamate  may occur,increasing the chance of side
      effects

       Porphyria-  meprobamate may make the condition worse  

11. Missed dose-
     If you miss a dose and remember withi 1 hour or so of the mssed dose,  takeit right away.
      However, if it is almost time for the next dose,  skip the missed dose and go back to your regular   dosing schedule.  Do not double doses.

12. Storage -
     Keep out of reach of children. Store away from heat or direct sunlight. Do not store the capsule    in bathroom, near the kitchen sink, or in other damp places.

13. Outdated medicines -
     Do not keep outdated medicine or medicine no longer needed. Be sure that any
     discarded medicine is out of reach of children.




 

Pharmacology
Meprobamate is an antianxiety agent,and a carbamate derivative that has selective side effects.
Mebrobamate is mildly tranquillising and and has some anticonvulsant and muscle relaxant
effect.

Pharmacokinetics:
It is well absorbed from the GI tract; peak plasma concentrations are reached within 1 to 3 hours.
liver metabolises 80 to 92%  of the drug. Following a single dose the plasma half-life ranges from
6 to 17m hours.

 

Reports not available

Pregnancy:
Use with exteme caution. Consider that a woman of a childbearing potential may be pregnant at
the time of institution of the therapy.

Lactaion:
 Excreted in the breast milk at concentrations 2 to 4 times of maternal plasma. The effect
of this amount of drug on the nursing infant is unknown.