Peripheral Vasodilators- Isoxsuprine hcl, Papaverine hcl, Hydralazine hcl, Minodoxil, Epoprostenol sodium, Tresprostinil sodium,

Papaverine +

Levodopa- the antiparkinson effectiveness may be decreased by concomittant administration of papaverine, due to possible blockade of dopamine receptors.

Smooth muscle relaxant, relief of cerebral and peripheral ischema

Peripheral Vasodilators- Isoxsuprine hcl, Papaverine hcl, Hydralazine hcl, Minodoxil, Epoprostenol sodium, Tresprostinil sodium,

Nausea, abdominal distress; anorexia, constipation, diarrhoea. Hepatic sensitivity, resulting in jaundice,eosinophillia and altered liver function tests. Vertigo, drowsiness, excessive sedation, headache. Increase in heart rate and depth of respiration, slight increase in blood pressure. Sweating, flushing of face; skin rash, malaise.

Complete AV block

Special precautions:

Glaucoma- use with caution. Hepatic hypersensitivity with GI symptoms- discontinue medication if these symptoms occur.

Drug abuse have been reported.

Indications: Smooth muscle relaxant, relief of cerebral and peripheral ischema

Dosage:

Oral- 300mg, 3 to 5 times daily Parentral- Administer 30 to 120mg every 3 hours

PAPVERINE - PERPHERAL VASODILATORS

1. May cause dizziness (hypotension) or drowsiness; use caution when driving or performing tasks requiring alertness. Alcohol may intensify these effects.

2. May cause flushing, sweating, headache, tiredness, jaundice, skin rash, nausea, anorexia, abdominal distress, constipation or diarrhea. Notify physician if these get pronounced

3. Allergy- Tell yor doctor if had any unuusal reaction to papaverine , food substances, preservatives,or dystuffs.

4. Pregnancy- Studies on effect in pregnacy not done

5. Breast feeding- Not known whether papaverine passes into breast milk. However, medicine not reported to cause any problems

6. Chldren- No specific information comparing use of papaverine in children with use in other age groups Medicine not expected to cause any different side effects than it does in adults.

7. Older adults- Papverine may reduce tolerence to cold temperaturs in elderly patients.

8. Other medicines- Tell your doctor if you are taking prescripion or non-prescription medicines

9. Other medical problems- Tell your doctor if you are having any of the following medical problems- Angina or Glaucoma or Heart disease or Myocardial infarction - recent or Stroke recent -chance of unwanted side effects may be increased

10. Dosing- Follow doctors instructions

11. Missed dose- If you miss a dose of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double doses.

12. Storage- Keep the medicines out of reach of children Store the medicines away heat and direct light Do not store tablets or capsules in the bath room, in damp places near the kitchen sink Heat and dampness will cause the medicines to break down Do not store out dated medicines or medicines no longer needed. Make sure that all discared medicines are kept out of reach of children

Peripheral Vasodilators- Isoxsuprine hcl, Papaverine hcl, Hydralazine hcl, Minodoxil, Epoprostenol sodium, Tresprostinil sodium,

Pharmacology:

Papaverine is an alkaloid derived from crude opium; it has no narcotic properties. Papaverine directly relaxes the tonus of all smooth muscle, especially when it has been spasmodically contracted. vasodilation may be related to its ability to inhibit cyclic nucleotide phosphodiesterase, thus increasing levels of intracellular cyclic AMP.

Pharmacokinetics:

Oral bioavialability is about 54%. Peak plasma levels occur 1 to 2 hours after an oral dose. Papaverine is metabolised in the liver. The drug is excreted in the urine in an inative form.

None reported.

Pregnancy: Safety for use during pregnancy has not been established. Use only when needed. Lactation: Safety for use in the nursing mother has not been established.

Children: Safety and efficacy for use in children heve not been established.