Antibiotics, barbitirates, or narcotics- allergic reactions have occured rarely during concomittant use of dexpanthenol

Succinylcholine- temporary respiratory dificulty occurred following dexpanthenol administration 5 minutes after administration of succinylcholine.

Succinylcholines effects appeared to have been prolonged. Do not administer within 1 hour of succinylcholine.

Prophylactic use after abdominal surgery to minimise thepossibility of paralytic ileus.

Itching, tingling, difficult breathing, red pathes,of skin,

generalised dermatitis, urticaria,

slight drop in blood pressure, intestinal colic,

vomiting, diarrhea, agitation in elderly patient.

Hemophilia, ileus due to mechanical obstruction.

Special precautions:

Mechanical obstruction- avoidance of drugs which decreases GI motility;

GI tract decompression when considerably distended by nasogastric suction or by use of intestinal tube.

Indications:
Prophylactic use after abdominal surgery to minimise thepossibility of paralytic ileus.

Dosage:
Postoperative-  250 to 500mg IM . Repeat in 2 hours followed by doses every 6 hours until danger of adynamic ileus has passed

Pharmacology:

Dexpanthenol is the alcohol analog of D-pantothenic acid. Pantothenic acid is a precursor of coenzyme A, which is a cofactor for enzyme-catalysed reaction involving transfer of acetyl groups.

Decreased acetylcholine content results in decreased peristalsis and in extreme cases, adynamic ileus. Dexpanthenols mechanism of action is unknown.

Pregnancy:

Give to a pregnant women only when clearly needed.

Lactation:

Excercise caution when administering the drug to a nursing mother.

Children:

Safety and efficacy in children have not been established.