PARADIONE *
Manufacturer Details
ABBOTT INC
Abbott Laboratories
Pharmacetical Division
Compositions:
Paramethadione 150mg caps,
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Strength
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Rate
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Packing Style
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150mg
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0.00
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Tab
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300mg
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0.00
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Tab
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List of Related Indications:
List Of Drugs:
- Paramethadione- @ - Oxizolinediones- Anticonvulsant
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Reports not available
Indication:
Petit mal seizures
ANTICONVULSANTS INCLUDES - BARBITURATES - OXAZOLIDINEDIONES- MISCELLANEOUS- Phenobarbitone Paramethadione Lamotrigine Trimethadione Primidone HYDANTOINS- Valproic acid Phenytoin BENZODIAPINES- Cabamazepine Mephenytoin Clonazepam Phenacemide Ethotoin Clorazepate Felbamate Diazepam Gabapentin SUCCINIMIDES- Ethosuximide Methsuximide Phensuximide REFER PHENYTOIN SODIUM -
Adverse Reaction:
Fatal nephrosis. Fatal aplastic anemia,hypoplastic anemia Skin rash, exfoliative dermatitis. Hair loss. myasthenia gravis symptoms, Vertigo, personality changes. Vomiting, abdominal pain, nausea, Anorexia, weight loss, Hiccups. Hepatitis.
Contra-Indications:
Hypersens to oxazolidones Special precautions: Withdrawal syndrome. Perform liver tests prior to initiating therapy. Perform urine analysis prior to therapy. Observe caution while treating patients who have diseases of retina or optic nerve. Perform a complete blood count before initating therapy.
Dosages/ Overdosage Etc:
Indications:
Petit mal seizures
Dosage:
Adults- 900mg to 2.4g/day in 3 or 4 equally divided doses (300 to 600mg 3 or 4 times daily) Children- 300 to 900mg/day in 3 or 4 equally divided doses.
Patient Information:
1.If GI upset occurs, may be taken with food.
2. Photosensitivity may occur. Avoid exposure to sunlight or ultraviolet light. Use sun screen and protective clothing
3. Do not discontinue abruptly or change dosage on advice of physician.
4. May cause drowsiness or blurred vision, observe caution while driving or performing tasks requiring alertness, coordination and physical dexterity
5. Notify physician if visual disturbances, excessive drowsiness or dizziness occurs
Pharmacology/ Pharmacokinetics:
ANTICONVULSANTS INCLUDES - BARBITURATES - OXAZOLIDINEDIONES- MISCELLANEOUS- Phenobarbitone Paramethadione Lamotrigine Trimethadione Primidone HYDANTOINS- Valproic acid Phenytoin BENZODIAPINES- Cabamazepine Mephenytoin Clonazepam Phenacemide Ethotoin Clorazepate Felbamate Diazepam Gabapentin SUCCINIMIDES- Ethosuximide Methsuximide Phensuximide REFER PHENYTOIN SODIUM -
Pharmacology: Unlike hydantoins and anticonvulsant barbiturates,neither drug modifies maximal seizure patter in humans receiving electroconvulsive therapy. These have a sedative effect which may increase to ataxia with excessive doses.
Pharmacokinetics: Readily absorbed from the GI tract. demethylated by liver microsomes to trimethidone, which is slowly excreted by kidneys. Trmethidone has a plasma half-life of 16 to 24 hours.
Interaction with Food:
Not significant
Pregnancy and lactation:
Pregnancy: Use with caution Lactation: Excercise caution and decide administration based on risk/benefit and importance of the drug to the mother.
