Drug Interaction:
Interacting agents- summary
Flucytosine +
Amphotericin B
flucytosine toxicity increased by increasing its cellular uptake or
impair or impair renal excretion
Cysosine
inactivate the anifungal activity of flucytosine
Indication:
Serious infections caused by strains of canidida or Cryptococcus
Adverse Reaction:
Respiratory arrest, chest pain, dyspnea. Rash,pruritus, urticaria, Photosensitivity. Nausea, emesis,
Abdominal pain, Diarrhea, anorexia, Dry mouth, duodenal ulcer, Haemorhage, hepatic dysfunction, Jaundice, ulcerative colitis, Bilirubin elevation.
Contra-Indications:
Hypersens to the drug
Dosages/ Overdosage Etc:
Indications:
Serious infections caused by strains of canidida or Cryptococcus
Dosage:
Usual dosage- 50 to 150mg/kg/day in divided doses at 6 hourly intervals. To reduce or avoid nausea or vomiting, take capsules a few at a time over 15 minutes.
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you ever had any unusual or allergic reaction to
flucytosine. Also tell your healthcare care professional if you are allergic to
any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Flucytosine has not been reported to cause cause birth defects or other
problems in humans. However studies in rats have shown that flucytosine
causes birth defects.
3. Breast-feeding-
Flucytoisine has not been reported to cause problems in nursing babies
4.Children-
This medicine is not expected to cause birth defects or other problems
in humans.
5.Older adults-
This medicine is not expected to cause different side effects or problems
in children than it does in adults.
6. Other medicines-
When you taking flucytosine it is especially important that doctor knows if you
are taking any of the following-
Amphotericin B or
Antithyroid agents or
Azothiaropine or
Chloramphenicol or
Ganceclovir or
Mercaptopurine or
Methotrexate or
Pilcamycin or
X-ray treatment - use of flucytosine with any of these medicines may increase
the chance of side effects of the blood
7. Other medical problems-
The presence of other medical problems may affect the use of flycytosine..
Make sure you tell your doctor if you have any other medical problems
especially-
Blood disease - flucytosine may cause blood problems
Kidney disease - patients with kidney disease may have increased
side effects
Liver disease- flucytosine may cause liver side effects
Pharmacology/ Pharmacokinetics:
Pharmacology:
Flucytosine has in vitro and vivo activity against Canidida and Crytococcus, but the exact mode is not known
Pharmacokinetics:
Well absorbed after oral use with peak serum levels in 2 hrs. About 80 to 90% of the drug is excreted unchanged in the urine
Pregnancy and lactation:
Pregnancy:
No adequate or well controlled studies studies on pregnant woman. Use only if the potential benefit outweighs the potential risk
Lactation:
Because of the potential serious adverse reaction to the nursing infant, either discontinue nursing or discontinue the drug.
Manufacturer Details