Reports not available

Schistosomiasis

Generally well tolerated. Tolerance improves when doses are given with food.

Transitory dizziness/drowsiness, headache, epileptiform convulsions(rare). Nausea, vomiting, abdominal pain, anorexia.

Special precautions:

Convulsion. Pregnancy, lactation.

Indications: Schistosomiasis

Dosage:

Adults- 12 to 15mg/kg as a single dose in patients with western hemisphere. strains of S mansoni.

Children- below 30kg- 20mg/kg given in 2 divided doses of 10mg/kg with 2 to 8 hrs between doses.

Pharmacokinetics:

Oxamniquine is well absorbed, plasma concentrations reach a peak at 1 to 1.5 hrs after oral administration of therapeutic dose, with a plasma half-life of 1t 2.5hrs. It is extensively metabolised to inactive acidic metabolites which are excreted the urine.

Can be taken with food

Pregnancy: Use only when clearly needed when the potential benefits clearly outweigh the potential risks to the fetus.

Lactation:

Excercise caution while administering the drug to the nursing mother.