Drug Interaction:
Mitotic inhibitors include- Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Drug interaction- summary
Sodium salicylate / Sulfamethizole / Tolbutamide + Tenoposide
Teniposide was displaced from protein -binding sites by these
agents to a small but significant extent. These small decreases in binding could cause
substantial increases in free drug levels, resulting in potentiation
of toxicity
Indication:
Mitotic inhibitors include- Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Adverse Reaction:
Myelosuppression 75% GI Mucositis 76% nausea/vomiting 29%
Dermatologic Alopecia 9% rash 3% Cardiovascular Hypotension 2%
Miscellaneous Fever 3% Infection 12% Bleeding 5%
Contra-Indications:
Hypersensitivity to teniposide
Warnings
Myelosuppression -Observe patients for myelosuppression during and after therapy
Monitoring- in ddition to haemolytic tests, carefully monitor renal and hepatic functions tests prior to and during therapy
Hypotension - administer by slow IV infusion since hypotension may occur with rapid IV injection
Downs syndrome- patients with both Downs syndrome and leukemia may be especially sensitve to myelosuppression therapy, therefore, reduce initial dosing with tenoposide in thes patients
Hepatic function impairment- excecise caution if tenoposide is administered to patients with hepatic dysfunction
Pregnancy- Avoid becoming pregnant
Lactation - because of potential for serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug depending on importance of the drug to the mother
Children- Tenoposide is indicated for use in children
Dosages/ Overdosage Etc:
Approved by FDA on July 14, 1992
Teniposide in combination with other approved anticancer agents for induction therapy in patients with refractory childhood lymphoblastic leukemia ( ALL )
Dosage:
Teniposide must be administered by IV infusion. Administer over 30 to 60 minutes or longer. Do not give by rapid IV injection. Hypotension has been reported following rapid IV administration.
Patient Information:
1. Contraceptive measures are recommended during treatment
2. Notify physician, if fever, chills, rapid heart beat, difficult breathing occurs
Pregnancy and lactation:
Pregnancy - Avoid becoming pregnant
Lactation- because of potential for serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug depending on importance of the drug to the mother
Children- Tenoposide is indicated for use in children
Manufacturer Details