SODIUM THIOSULFATE INJ *
Manufacturer Details
PASADENA INC
Compositions:
Sodium thiosulfate 25% inj,
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Strength
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Rate
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Packing Style
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25%
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0.00
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Tab
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List of Related Indications:
- Antidote for cyanide poisoning
List Of Drugs:
- Sodium thiosulfate -Antidotes for Ardenic, Cyanide
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
None reported
Indication:
Cyanide poisoning
Adverse Reaction:
None reported
Contra-Indications:
Not reported
Special precautions-
Warnings-
Pregnancy-
Use only when needed and when the potential benefits outweigh the potential hazards to the fetus.
Dosages/ Overdosage Etc:
Indication:
Cyanide poisoning
Dosage:
Adults- 12.5g IV over 10 m inutes, whether used alone or in combination with other cyanide antidotes
Children-7g/m2 , maximum dose is 12.5g
Pharmacology/ Pharmacokinetics:
Pharmacology:
The primary mechanism of cyanide detoxification involves conversion of cyanide to the relatively nontoxic thiocyanate ion. This reaction involves the enzyme rhodanase (tuocyasulfate cyanide sulfurtransferase) found in many body tissues, but with major activity in the liver.
Pharmacokinetics:
The biological half-life is 0.65 hrs.
Pregnancy and lactation:
Pregnancy:
Use with caution, only if required
