Interacting drugs- summary

Heparin and aminoglycoside - inhibit the enzyme, 

Salicylates and NSAIDs - inhibit the spreading action.

Urokinase -Action potentiated by urokinase especially in the treatment of myocardial infraction.

Local anaesthetics - Increases diffusion of local anaesthetics.

Adjuvant to increase the absorption and dispersion of other injected drugs. 

Hypersensitivity and anaphylaxis.

Urticaria spread of local infection.

Opthalmic prepn: No ADR reported.

Hypersensitivity,local malignancy or infection.

Special precautions:

Impaired renal function.

For I.V. admin only highly purified preparation.

Pregnancy.

Indications:

Adjuvant to increase the absorption and dispersion of other injected drugs.

Dosage:

Lyophilised powder for injection- add 1ml of 0.9% sodium cjloride to a vial containing 150u, so as to make 150u/ml.

Storage:

Keep in a dry place. Sterile reconstituted solution may be stored below 30C for 2 weeks without significant loss of potency.

Pharmacology:

Hyaluronidase, a protein enzyme, is a preparation of highly purified bovine testicular hyaluronidase. The exact chemical structure of the enzyme is unknown.

Hyaluronidase is a spreading or diffusing substance which modifies the permeability of a connective tissue through the hydrolysis of hyaluronic acid, a polysaccharide found in the intracellular ground substance of connective tissue, and of certain specialised tissues .

The rate of diffusion is propionate to the amount of enzyme.

Pregnancy:

It is not known whether hyaluronidase can cause fetal harm when administered to pregnant women. Use only if clearly needed.

Lactation:

Excercise caution when hyaluronidase is administered to a nursing woman.