Bronchodilators- include Albuterol, Biotolterol, Ephedrine,Ephinephrine, Ethylnorepinephrine, Isoetharine, Isoproterrenol, Metaproterenol, Pirbuterol, Salmeterol, Terbutaline

Refer- Ephedrine- Inhalation

Improved respiratory function when combined with beclomethasone, theophylline.

Action of sympathomimetic bronchodilators inhibited by beta-blockers.

Food reduces bio-availability.

Bronchial asthma 

Very rare, pulmonary oedema (during pregnancy). Fine skeletal muscle tremor, especially in hands, tachycardia, palpitations, peripheral vasodilatation, hypotension, nausea, headache, drowsiness, nervousness. Tolerance. 

Inhalation: If usual dose does not provide relief, non-responsive state may develop in which case aerosol may prove harmful (worsening of hypoxemia)

. Swallowing of inhalation may cause epigastric pain.

Hypersens to sympathomimetic amines. Cardiac patients with associated arrhythmias. After antipartun haemorrhage, toxemia of pregnancy.

Special precautions:

Hypertension. Hyperthyroidism. Cardiac patients, pregnancy.

Date of Approval   1982

Indications:

Bronchial asthma

Dosage:

Inhalation adults and children below 12 years- 2 inhalations separated by 60 seconds every 4 to 6 hours.

Do not repeat more often than every 4 to 6 hours.

Oral- adults and children below 15 years- 5 mg given at 6 hours intervals, 3 times daily during waking hours.

If side effects are produced the dose may be decreased.

Not recommended for children below 12 years of age.

 1. Do not exceed the recommended dosage, excessive use may lead to adverse effect or loss of efectiveness.

2. Do not stop or adjust the dose.

3. Do not change brands without consulting the physician or the pharmacist.

4. If more than one inhaltion is necessary,wait for at least one full minute between inhalitions (administer the second inhalation at 3 to 5 minutes for isoproternol and epinephrine, 2 minutes for metoproternol ).

5. Notify physician of failure to respond to usual dosage or of dizziness or chest pain. 6. Isopreternol may cause the patients saliva to turn pinkish-red.

Refer sympathomimetics- bronchodilators

Refer sympathomimetics- bronchodilators

Refer sympathomimetics- broncodilators