Interacting drugs

 Alderonate  +  Aspirin      -  increased adverse GI effects

Bismuth sub salicylate +  Aspirin       -    increased adverse effects

Ticlopodine  +  Aspirin        - increased platelet aggregation

Aspirin +  Nitrates           -    increased action of nitrates

Aspirin  + Metoclopramide    -     increased absoprtion of Aspirin

Aspirin  + Rimantadine         -    peak plasma levels decreased

Ticlopodine potentiated the effect of aspirin on collagen-induced platelet aggregation.

Ticlopidine mediated inhibition of ADP -induced platelet aggregation is not affected. Co-administration is not recommended

 May potentiate anticoagulants,hypoglycaemics,methotrexate, tricyclic antidepressants.

PABA may increase serum levels. Urinary alkalisers,antacids,corticosteroids may increase excreation.

May antagonise uricosuries,spironoalctone.

Mild to moderate pain.fever,

Various inflammtory condotions. such as rheumatic fever,

Rheumatoid arthiritis

GI toxicity includes gastric erosion,ulceration and bleeding

.Patients with asthma suffers severe occasionally fatal exacerabation of airway obstruction.

Cerebral haemorrhage especially in patients with pre-existing vascular lesion.

Reyes syndrome(children below 12yrs).

GI disturbances.

Prolonged bleeding time,rhinitis,urticaria, and epigastric comfort.

Sensitivity to aspirin,active peptic ulceration,platelet disorders.

Aspirin taken during last 3 mths of pregnancy may cause bleeding problems in both mother & child.

Not to be given to children under 12yrs.

Special precautions:

History of bronchospasms,

Aspirin/NSAID induced allergy,  Impaired renal or hepatic function.

Dyspepsia. Elderly.

Indications:

Mild to moderate pain.fever  ,various inflammatory conditions. such as rheumatic fever,   rheumatoid arthritis and osteoarthritis and

reducing risks of transcient ischemic attacks. or strokes in men,

reduce risk of death or nonfatal infarction.

In patients with prevoious infaction or unstable angina.

Dosage:

Minor aches and pain- 325 to 650mg every 4 hours as needed.

Arthiritis and rheumatoid conditions- 3.2 to 6g in divided doses.

Juvenile rheumatoid arthiritis - 60 to 110mg/kg/day in divided doses(every 6 to 8hrs), starting from 60mg/kg/day..

May be increased by 20mg/kg/day after 5 to 7 days followed by 10mg/kg/day after another 5 to 7 days.

Myocardial infarction prophylaxis- 300 to 325mg/day.

Children- Analgesic/antipyretic - 10 to 15mg/kg/day every 4 hours upto 60 to 80mg/kg/day .

Do not use in children or teenagers with chickenpox or flu due to possibility of reyes syndrome.

ASPIRIN- SALICYLATES Include- salicylates, choline salicylate, sodium salicylates

REFER - ASPIRIN

1.May cause GI upset,take with food or after meals.

2.Do not crush or chew sustained release preparations..

3.Take with a full glass of water (240ml) to reduce the risk of lodging medication in the esophagus.

4.Patients allergic to tartrazine dye should avoid aspirin.

5.Notify physician if ringing in ears or persistent GI pain occurs.

6.Do not use aspirin if it has a strong vinegar-like odour.

Pharmacology:

Salicylates have analgesic,antipyretic,anti-inflammatory and antirheumatic effects. Salicylates lower body temperature through vasodilation of perpheral vessels,thus enhancing dissipation of excess heat.

Pharmacokinetics:

Salicylates are rapidly and completely absorbed after oral use. Bioavailibility is dependent on the dosage form.presence of food,gastric emptying time,gastric pH, presence of antacids or buffering agents and particle size.

Bioavailabilty of some enterc coated tablets may be erratic.

May cuase GI upset. Can be taken with food.

Refer Salicylates, Aspirin