Glimepiride 1mg/2mg tablets,
List of Related Indications:
- Non-insulin dependent diabetes mellitus - NIDDM patients
List Of Drugs:
- Glimepiride-@-( ** )-Sulfonylureas-Hypoglycemic- (FDC- List )- (Nov 1995)
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Sulfonylureas- include- First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide
Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide
Dizziness, asthenia, headache, nausea, gastrointestinal pain, cholesstatic jaundice, pruritus, urticaria
Hypersensitivity to the drug Diabetic ketoacidosis with or without coma.
Long term efficacy of glimepiride should be monitored Not recommended for use during pregnancy, nursing mothers, or children. Patients planning pregnancy are recommended to change over to Insulin therapy for the entire course of pregnancy. Elderly, debilated or mal nourished patients, hepatic insufficiency Impaired renal function
Dosages/ Overdosage Etc:
Approved by FDA November,1995
Non-insulin dependent diabetes meilltus
Initial dose- 1 to 2mg once daily,given with breakfast or first main meal.
Patients sensitive to hypoglycaemic drugs may begin at 1mg once daily.
Maximum starting dose is less than 2mg.
Sulfonylureas- include- First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide Refer Chlorpropamide
Not to be used during pregnancy and lactation
Pharmacology Glimepiride differs from other sulphonylureas in exhibiting its preferences in receptor binding properties .
Pharmacokinetics following oral administration, glimepiride was found to be completely absorbed from the GI tract. Peak plasma levels were attained within 2-3 hours of administration.
Interaction with Food:
Equally effective in reducing concentrations of fasting, post-breakfast and post-dinner plasma glucose.
Pregnancy and lactation:
Not recommended during pregnancy and lactation Not recommended for use in children