Fluoroquinolones include the following : Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin Refer Ciprofloxacin 

Interacting drugs-summary-

Administration of levofloxacin with antacids containing magnesium or aluminium as well as sucralfate, metal cations, such as iron, and multi-vitamin preparations with zinc may interfere with gastrointestinal absorption of levofloxacin resulting in systemic levels considerably lower than desired.

Urinary and respiratory tract infection 

Fluoroquinolones include the following :

Ciprofloxacin, Norfloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Enoxacin

Refer Ciprofloxacin                                                                              

Nausea, Diarrhea, vaginitis, flatulanace, Puritus, rash, abdominal pain, genital monoliasis, Dizziness, dyspepsia, insomnia,

Taste perversion, vomiting, anorexia, Anxiety, increased sweating, leukorrhea, Malaise, nervousness, Sleep disorders, tremor, Urticaria, headache, Constipation.

Levofloxacin is contraindicated in persons with a history of hypersensitivity to levofloxacin and quinolone antimicrobial agents or any other components of the product.

Special precautions:

Safety and efficacy of levofloxacin in children, adolescents (under age of 18 years) pregnant women have not been established.

Pseudomembraneous colitis has been reported with nearlly all antibacterial agents, including levofloxacin and may range in severity from mild to life threatening.

Ruptures of the shoulder, hand and achilles tendons that required surgical repair or resulted in prolonged disability have been reported in patients receiving quinolones.

Convulsuions and toxic psychoses have been reported in patients receiving levofloxacin. The use of the drug should be discontinued.

Urinary and respiratory tract infection

Dosage-

Usual dose is 500mg once daily: acute sinusitis (10-14 dats)

Refer Fluroqionolones - Ciprofloxacin

Pharmacology:

Levofloxacin is the L-isomer of the racemate , Ofloxacin a quinolone antimicrobial agent. The antibacterial activity of Ofloxacin resides primarily in the L-isomer. The mechanism of action levofloxacin and other fluoroqinolones antimicrobials involve the inhibition of bacterial topisomerase IV and DNA gyrase(both of which are type II toposomerases), enzymes required for DNA replication, transcription, repair, and recombination.

Levofloxacin has "in vitro" activity against a wide range of Gram negative and Gram positive microorganisms and is often bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.

Pharmacokinetics:

Levofloxacin is rapidly and essentially completely absorbed after oral administration. Peak plasma concentrations are usually attained one to two hours after oral dosing. The absolute bioavilability of a 500mg oral dose is approximately 99%. Steady state is reached within 48 hours following a 500mg once daily dose regime. The peak and trough plasma concentrations were approximately 5.7 and 0.5 mcg/ml repectively. The mean terminal plasma eliminatoin half-life of levofloxacin ranges approximately from 6 to 8 hours following single or multiple doses of levofloxacin given orally or intervenously .

Safety and efficacy of levofloxacin in children, adolescents (under age of 18 years) pregnant women have not been established.