Selective serotonin reuptake inhibitors include-

Fluoxetine, Fluvoxamine, Paroxetine, Sertraline,  Citalopram, Escitalopram
Refer- Fluoxetine

Interacting drugs- summary

Serataline +

 Benzodiapines
 Clearance of benzodiazepines decreased

 Lithium
 Lithium levels may be increased by fluoxetine

 Tolbutamide 
  Sertraline decreased the clearance of tolbutamide

Treatment of depression

Selective serotonin reuptake inhibitors include-

 Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Escitalopram

Refer- Fluoxetine 

Approved by FDA in December 1991

New Drugs Approved by (DCI) Drug Controller  GENERAL -  India  For Marketing                                                                                                       (Ref- IDMA Publication)

Selective serotonin reuptake inhibitors include-

Fluoxetine, Fluvoxamine, Paroxetine, Sertraline,  Citalopram, Escitalopram
Refer- Fluoxetine

Adverse Reactions-

SERTRALINE-

  BODY AS A WHOLE -   Headache, Asthenia, Abdominal pain, Fever ,Chest pain   

   CARDIOVASCULAR -    Palpitations, Hot flushes  

    CNS -      Insomina,16% Somnolence 13% ,Nervousness 3%,Anxiety 2% ,                                             Dizziness 11%  Tremor 11% Fatigue 10% 

     GI-           Nausea 26% Vomiting 3% Diarrhea 17% Dyspepsia 6%  Dry mouth 16%                              Anorexia 3% Constipation 8% Flatulance 3%

      RESPIRATORY-      Yawn 2%

      SKIN-      Sweating 8% Rash 2% Pruritus 1%

      SPECIAL SENSES-      Blurred vision  4% Taste perversion 1%

       GU-         Menstruation painful 1% Urinary frequency 1.5% Urinary disorder 1.4%

Refer Fluoxetine

Approved by FDA in December 1991

Indications:

Treatment of depression

Dosage:

Initial : 50mg once daily ,either in the morning or evening.

Patients not responding to a 50mg dose may benefit from dose increases up to a maximum of 200mg/day.

Given 24 hour elimination half-life of setraline,dose changes should not occur in intervals of less than 1 week.

SERTALINE - SELECTIVE SEROTNIN REUPTAKE INHIBITORS

1. May cause dizziness. Observe caution while driving or performing tasks requiring alertness, coordination or physical dexterity

. 2.Avoid alcohol or other CNS depressants medicines.

3. Concomitant medication- Consult physician or pharmacist before taking concomittant OTC products or prescription drugs

4. Pregnancy or lactation- Notify physician of pregnancy, or intent to become pregnant or if breast feeding

5. Rash- Notify physician if rash hives develop

. 6.Completing course of therapy- While patients may notice improvement in therapy in 1 to 4 weeks, advise patients to continue therapy as directed.

7. Allergies- Tell your doctor if you ever had any unusual or allergic reaction to sertaline . Also tell your doctor if you are allergic to any other substances such as preservatives, foods, or dyes. etc.

8. Pregnancy- Studies have not been done on pregnant women. However studies in animals have shown that sertaline may cause delayed and decreased survival rates of offspring when given in doses many times the usual human dose. Before taking this medcine make sure that your doctor knows if you are pregnant or if you become pregnant

. 9. Breast feedng- Not known whethr sertailine is excreted in breast milk.

10. Children- Studies have been done only in dult patients,and thereis no specific information comparing use of sertatiline with use in other age groups.

11. Older adults- Studies doneon elderly people did not cause different side effects or problems in older people than it did in younger adults.

12. Other medicines- Tell your doctor if your taking any other  medicines- Digitoxin or Warfarin -higher or lower blood levels of thee medicines or sertalitine may occur.,which may increase the chance of unwanted effects. Your doctor may need to change the dose of these medicines or sertaline.

  13. Other medical problems- Tell your doctorwould like to know  if you had any other  medical problems- Drug abuse or dependence - it could be habit forming.,causing mental or physical dependence.  Kidney disease or Liver diseases - higher blood levels may occur, increasing the chance of side effects.

13. Missed dose- if you miss a dose and dosing is Once a day at bed time- do not take mised dose in the morning since it may cause disturbing side efects during waking hours. check with your doctor More than one dose a day- take the mised dose as soon as possible. However if it is almost time for the next dose , skip the missed dose and go back to your regular schedule. Do not double doses.

14. Storage- Keep out of reach of children. Overdose of this medicine is too dangerous for children. Store away from heat and direct light. Do not store the tablet or capsule form of this medicine in the bathroom,near the kitchen sink or in other damp places Keep the liquid formof this medicine from freezing Do not keep outdated medicines. Be sure that discarded medicine is out of reach of children

Refer fluoxetine

Not available

Refer fluoxetine