May interfere with the response of live measle vaccine, live mumps vaccine, live rubella vaccine and live varicella vaccine Should be given at least 3 weeks before or 3mth after the admin. of the immuoglobulins

Control of outbreaks of hepatitis A Prophylaxis against hepatitis A in immunocomprised patients

Dizziness, light-headedness, Nausea, vomiting, Cutaneous reactions Local pain and tenderness at the inj site I.V. admin. may lead to systemic effects such as headache, chills and fever

Patients with selective 1gA deficiency Prior anaphylactic reactions to imunoglobulin, Blood or blood derived preparations

Special precautions-

Inceased risk of ARF in patients with renal impairment High infusion rate may increase risk of adverse reactions Ensure adequate hydration prior to IV infusion of immunoglobulin Monitor urine output and serum creatinine during treatment Avoid concurrent use of loop diuretics during IV infusion Live vaccines should be given 3 weeks before or 3mths after admin. of normal immunoglobuin

Indication-

Control of outbreaks of hepatitis A

Dosage-

Prophylaxis against hepatitis A in immunocomprised patients 500mg via deep IM inj

Child- recommended dose < 10yr 250mg > 10yr 500mg to be given as deep IM inj