Reports not available

Acute gonorrheal urethritis and proctitis

In and multiple dose studies in healthy volunteers a reduction in urine output was noted. however, renal toxicity has not been demonstrated. Single dose- sore injection site, urticaria, dizziness, nausea, chills, fever, insomnia Multiple doses- decrease in hemoglobin, hemotocrit and creatinine clearance, elevation of alkaline phosphsatase BUN, and ALT

Hypersensitivity to spectinomycin

Special precautions-

Monitoring- Monitor clinical effectiveness to detect resistence by N gonorrhoea The dilulent provoded with this product contains benzyl alcohol which has been associated with a fatal gasping syndrome in infants.

Hypersentivity- a few cases of anaphylaxis or anaphylactoid reactions have been reported. Have epinephrine immediately available.

Indications:

Acute gonorrheal urethritis and proctitis

Dosage:

Initial treatment with 4g (10ml) IM preferred, and may be divided betwen 2 gluteal sites

Pharmacology-

Spectinomycin structurallt different from related aminoglycosides inhibits protein synthesis in bacteria cell. Site of action is 30S ribosomal unit.

Pharmacokinetics-

Rapidly absorbed after Im injection . a 2g injection produces average peakserum concentrations of 100mcg/ml at 1 hour a 4g injection, 160mcg/ml at 2 hours. Eight hours after a 2g or 4g injection, plasma concentrations are 15 and 31mcg/ml respy. The majority is excteted in urine inbiologicaly active form

Microbiology-

Active in vitro against most strains of Neiseria gonorrhoeae ,studies show no cross-resistence between spectinomycin and penicillin.

Pregnancy:

Safety for use in pregnancy has not been established

Children:

Safety for use has nort been established