Interacting drugs- summary

- Corticosteroids                                                                                                               growth-promoting effect of somatrem inhibited 

Long term treatment of children who have growth failure due to lack of adequate growth hormone secretion 

Somatrem - approx 30 to 40% of all patients developed persistent antibodies Somatropin- approx 2% of patients developed antibodies

Sensitivity to benzyl alcohol used as diluent with the product

Precautions-

Insulin- resistence may be induced by growth hormones, observe for glucose intolerance

Hypothyroidism - may develop durin therapy, untreated it may prevent optimal response to therapy perform periodic thyroid function tests, use thyroid hormone when indicated

Long term treatment of children who have growth failure due to lack of adequate growth hormone secretion

Dosage-

Upto 0.1mg/kg ( 0.26 IU/kg ) SC or IM 3 times per week is recommended.

Becuase of potential side efects do not exceed this dose

Growth hormone-

1. Inform patients being treated with growth hormone or teir parents of the potential benefits and risk associated with the treatment.

2. If home use is determined use is determined to be desirable by the physician give instructions on appropiate use, including a review of the contents of patient information insert

3. If home use is prescribed recommend a puncture resistent container for disposal of used syringes and needles.

4. Throughly instruct patients or parents in the importance of proper disposal and caution against any reuse of needles and syringes

Pregnancy - Give to pregnant women only if clearly needed

Lactation- Excecise caution when administering to nursing mother