Drug Interaction:
Immunisation against rubella
Interacting drugs- summary
+Rubella vaccine-
Immunosuppressants
administration of rubella vaccine to patients receiving
immunosuppressants including corticosteroids or radiation therapy,
may result in insufficient response to immunisation.
Immune globulins
to avoid inactivation of the attentuated virus, administer the vaccine at
least 14 to 30 days before or 6 to 8 weeks after the immune globulin.
Check antibody titers or repeat the vaccine dose 3 months after 1gG.
Interferon
concurrent administration inhibit antibody response to the vaccine
Meningococcal vaccine
reduced seroconversion rate to meningococcal occur with
concurrrent immunization
Virus vaccines, others
to avoid hypothetical concern over antigenic competition give rubella vaccine,
after or > 1 month before other vaccines. However, several vaccines
given simulatneously at separate injection sites (eg. DTP, OPV,MMR, Hib,
Hepatitis B).
Indication:
Immunisation against rubella
Adverse Reaction:
Reactions are usually mild and transcient. because the vaccine is slightly acidic patients may experience burning or stinging of short duration at the injection site.
Symptoms that normaly occur are- regional lymphadenopathy, urticaria, rash, malaise, sore throat, fecer, headache, polyneuritis, temporary arthalgia (infrequently associated with inflammatin). Local pain. induration and erythema may occur at the injection site.
CNS- encephalitis and other CNS reactions, erythema multiforme, optic neuritis and polyneuropathy (including Gullian-Borre syndrome ) may occur. Arthritis/arthalgia- chronic arthiritis has been associated with natural ribella infection.
Contra-Indications:
Pregnancy. History of hypersensitivity reactions to this vaccine of any of the components, patients receiving immunosuppressive therapy, blood dyscrasis, leukemia, lymphoma of any type. or malignant neoplasms affecting the bone marrow or lymphatic systems, primary oracquired immunoficiency , active untreated tuberculosis, family history of congenital or heridiary immunodeficiency, until the immune competence of the potential vaccine receipent is demonstrated.
Do not vaccinate persons who are immunosuppressed in association with AIDs or other clinical manifestations of infection of HIV , cellular immnue deficiencies, and hypogammaglobulinemic and dysgammaglobulinemic states Defer imminuzation during the course of any acute illness.
Warnings-
Immunodeficiency- do not use in immnuodeficient persons, including persons with congenital or acquired immune deficiencies, whther due to genetics, disease or drug or radiation therapy.
Contains live virus. Nonetheless, routine immmnization of sympatomatic and asymptomatic HIV-infected persons with MMR is recommended.
Hypersensitivity- have epinephrine 1:1000 available to control immediate allergic reactions.
Pregnancy- Do not intentionally give attenuated rubella vaccine to pregnant females.
Lactation- Vacine- strain virus is secreted in breast milk and may be transmiitted infants. Children- Safe and effective for childen > 12 months of age. Vacination is not recommended for children < 12 months of age.
Dosages/ Overdosage Etc:
Immunisation against rubella
Dosage-
Inject total of reconstituted vaccine SC into outer aspect of the upper arm.. Do not inject IV or administer intranasally.
Missed dose-
1. If you miss a dose of this medicine, and remember it on the day it should be taken, take it as directed.
2. However, if you do not remember the mised dose until the next day,take the missed dose at that time and reschedule your every-other-day doses from then.
3. It is important that this vaccine be taken exactly as directed so that it can give you protection against Rubella.
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
RUBELLA VIRUS VACCINE- SYSTEMIC
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Rubella Virus Vaccine. Also tell your healthcare care professional if you
are allergic to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
Tell your doctor if you are pregnant or intend to may become pregnant within
3 months after receiving this vaccine. Although studies have not been done
in humans, use during pregnancy is not recommended
3. Breast-feeding-
Rubella vaccine may pass into breast milk and may cause mild rubella infection
in nursing babies. However,studies have not shown that this infection causes
any problems.
4.Children-
Use is not recommended for infants younger than 12 months.This medicine has
been tested in older infants and children and in effective doses, has not been
shown to cause different side effects or problems than it does in adults.
5. Other medicines-
Tell your doctor if you are using any of the following -
Cancer medicines or
Corticosteroids or
Radiation therapy - may reduce the useful effect of the vaccine
6. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
especially-
Immune deficiency condition- condition may increase the chance and
severity of the vaccine and may decrease the useful effect of the vaccine
Severe illness with fever - the symptoms of the condition may be confused
with the possible side effects of the vaccine
Tubrculosis - use of rubella vaccine may interfere with the tuberculin
skin test
Pharmacology/ Pharmacokinetics:
Pharmacology-
Onset of rubella vaccine is 2 to 6 weeks. It induces HI antibodies in at least 97% of susceptible children.
Pregnancy and lactation:
Pregnancy-
Do not intentionally give attenuated rubella vaccine to pregnant females.
Lactation-
Vacine- strain virus is secreted in breast milk and may be transmiitted infants.
Children-
Safe and effective for childen > 12 months of age. Vacination is not recommended for children < 12 months of age.
Manufacturer Details