Drug interactions- summary

PABA +

Dapsone-                                                                                                                          dapsones antimalarial effect may be antagonised by PABA due to interference with its primary mechanism of action Procainamide

PABA inhibits procainamide -                                                                                              conversion to N-acetyl procainamide and it inhibits renal excetion of N-acetylprocainamide

Effective in treatment of scleroderma

Anorexia Nausea Fever Rash

Concurrent sulfonamide use (PABA inhibits the bacteriostatic activity of sulfonamides)

Safety prcautions-

Anorexia or nausea- should anorexiar nausea occur interrupt therapy until the patient is eating normally again. This avoids the possdibilty of hypoglycemia.

Hypersentivity- if hypersentivity reactions occur, discontinue the drug

Warnings- Renal functon impairment- use cautiously

Pregnancy- Safety for use during pregnancy has not been established. Use when clearly needed and when potential benefits outweigh potential hazards of the fetus.

Lactation- use only when clearly needed.

Indication-

Effective in treatment of scleroderma

Dosage

Take with food. Take tablets witrh an adeqiate amount of water to prevent GI upset. Adults- 12 g daily in 4 to 6 divided doses. As dietary supplement, take one tablet daily. Children- 1g/10 ib (4.55Kg) daily in divided doses.

Storage/stabilty- store powder in a tight light resistent container. Overdosage- Symptoms Nausea, vomiting are most common Depression of the leukocyte count and an alleged fatal case of toxic hepatitis have occured

1.Take with food.

2.Take tablets witrh an adeqiate amount of water to prevent GI upset.

Pharmcology-

PABA is a component of of several biological systems and participates in a number of biologic processes. By increasing oxygen supply at the tissue level PABA enhances MAO activity and prevents or causes ,regression of fibrosis. These effects are speculative.

Pregnancy-

Safety for use during pregnancy has not been established. Use when clearly needed and when potential benefits outweigh potential hazardsof the fetus.

Lactation-

Use only when clearly needed.