Drug Interaction:
Antiemetics/ Antivertigo agents-
include Phenothiazines- Chlorpromazine Nausea /Vomiting Triflupromazine Nausea /Vomiting Perphenazine Nausea /Vomiting Promethazine Nausea /Vomiting Motion Sickness Prochlorperazine Nausea /Vomiting Others- Metoclopramide Nausea /Vomiting Anticholinergics- Antihistamines- Cyclizine Nausea /Vomiting Motion Sickness Meclizine Nausea /Vomiting Motion Sickness Vertigo Buclizine Motion Sickness Diphenhydramine Nausea /Vomiting Motion Sickness Vertigo Dimenhydrinate Nausea /Vomiting Motion Sickness Verigo Others- Trimethobenzamide Nausea /Vomiting Scopolamine Motion sickness Miscellaneous- Diphenidol Nausea /Vomiting Vertigo Benzquinamide Nausea /Vomiting Phosphated carbh } Nausea /Vomiting hydrated solution } Hydroxyine Nausea /Vomiting Corticosteroids Nausea /Vomiting Cannabinoids Nausea /Vomiting
Refer Chlorpromazine
Alcohol,sedatives & other CNS depressants potentiated. Synergism with paracetamol and codeine phosphate in aborting migraine attack.
Potentiates other CNS depressants(sedatives,hypnotics,antihistamines,opiates and alcohol). Anticholinergic crisis with antiparkinsons agents and tricyclic antidepressants. Additive orthostatic hypotension with MAOIs. Reverse anti-hypertensive effect of guaneththidine, methyldopa and clonidine.Additive sedative effect with alcohol.
Indication:
LIST OF DRUGS DURING 2006
Sr.No- 71
Name of the Drug- Buclizine HCL tablet 25mg & syrup 6mg/5ml Pharmacological Classification- As appetite stumulant
Date of Approval- 28-06-2006
Approved by U.S.FDA on 30-12-2006 (Ref- FDA approved List)
Nausea and vomiting Pscychiatric disorders
Antiemetics/ Antivertigo agents- include Phenothiazines- Chlorpromazine Nausea /Vomiting Triflupromazine Nausea /Vomiting Perphenazine Nausea /Vomiting Promethazine Nausea /Vomiting Motion Sickness Prochlorperazine Nausea /Vomiting Others- Metoclopramide Nausea /Vomiting Anticholinergics- Antihistamines- Cyclizine Nausea /Vomiting Motion Sickness Meclizine Nausea /Vomiting Motion Sickness Vertigo Buclizine Motion Sickness Diphenhydramine Nausea /Vomiting Motion Sickness Vertigo Dimenhydrinate Nausea /Vomiting Motion Sickness Verigo Others- Trimethobenzamide Nausea /Vomiting Scopolamine Motion sickness Miscellaneous- Diphenidol Nausea /Vomiting Vertigo Benzquinamide Nausea /Vomiting Phosphated carbh } Nausea /Vomiting hydrated solution } Hydroxyine Nausea /Vomiting Corticosteroids Nausea /Vomiting Cannabinoids Nausea /Vomiting
Refer Chlorpromazine
New drugs approved For Marketing by Drug Controller General of India(DCGI ) during the period January 1988 to November 2014 (Ref- IDMA Annual Publication 2015)
Name of Drug Indication Date of Approval
1.Buclize hcl 25mg tablet 16-01-2010
Addl.indication
2.Buclize hcl 25mg & syrup 6mg/5ml 28-06-2006
As appetite stimulant
Adverse Reaction:
Blood dyscrasias,ventricular tachyarrhythmias, malignant neuroleptic syndrome.
Blurred vision,dry mouth, urinary hesitancy/retension, constipation,orthostatic hypotension, allergic rash, akanthisia,dystonias, muscle weakness,anorexia,insomnia.
Drowsiness, dry mouth, nose & throat, Nervousness, restlessness, headache, depression, nausea, epigastric pain, weight gain and diarrhoea.
Contra-Indications:
Coma.Severe depression due to alcohol or centrally acting depressants. Parkinsons disease. Hypersens. 1st trimester of pregnancy. Hypersens.
Special precautions:
Epilepsy,narrow angle glaucoma,myasthenia gravis.BHP.
Caution combining with anti-depressants or anti-coagulant drugs.
Safety in pregnancy not established, elderly debliterated.
Driving, operating dangerous machinery.
H/O renal disease.
Dosages/ Overdosage Etc:
As appetite stimulant
Indications:
Motion sickness Nausea and vomiting Pscychiatric disorders
Dosage:
50mg dose usually alleviates nausea. Severe cases 150mg/day can be taken. Maintenance dose 50mg 2 times daily. Take atleast half an hour before travel.
Patient Information:
Refer Chlorpromazine
Interaction with Food:
Take within 1/2 hr before meals
Manufacturer Details