Concurrent use increases digoxin concentration.

Increase risk of lithium toxicity Increases risk of hyperkalemia with K sparing diuretics

Heparin

INFORMATION- UPDATE

TELMISTRAN - MODEST INCREASE IN CANCER RISK

TELMISTRAN

CNS -

Dizziness 1% ,Insomnia  >0.3%,  Headache 1% ,Fatigue 1% Anxiety/nervousness ,Depression  > 0.3%

GI -    

Diarrhea 3% Dyspepsia /heartburn 1% Nausea/vomiting 1% Abdomnal pain 1%     

Musculoskeletal-

Arthalgia > 0.3% Pain  3%   Myalgia 1% 

Respiratory -  

Upper Res tract infn 7% Cough 1%  Sinusitis 3% Pharyngitis 1% Rhinitis 0.3%
 Influnz  symptoms  1% Bronchitis 0.3%

Miscellaneous-

Chest pain 1% Rash > 0.3%  Tacycardia > 0.3% Urinary tract infn 1%
Peripheral edema   1%   Hypertension 1%
                            

Severe hepatic impairment,  Biliary obstructive disorders

Pregnancy Lactation

Special precautions-

Hepatic insufficiency , Biliary obstructive , renal impairment

Renaly artery stenosis.

Correct volume depletion before initiating treatment

Monitor serum K levels regularly, especially in elderly and renally impaired patients

Indication-

Hypertension

Dosage

Adults 40mg once daily Max 80mg /day

Use contraindicated during pregnancy and lactation.

Observe caution if use is needed