Pharmacology/ Pharmacokinetics:
Pharmacology- Metadoxine is an ion-pair consisting of pyridoxine with pyrolidone carboxylate> Some researches have suggested that the effect of metadoxine is loely attributed to the biotransformation of alcohol into less harmful compounds, mainly rapidly eliminated higherr ketones resulting in more rapid lowering of alcohol and acetaldehyde concentration in blood and tissues. In animal pharmacology data suggest that metadoxine may have direct effects on the central nervous system CNS that are independent of any effect on alcohol metabolism Clinical efficay- In patients with alcoholic fatty liver metadoxime accelrates the normalization of liver function tests and the ultrasono-graphic changes even in those who do not completely abstain from alcohol intake
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