Drug Interaction:
Fenofibrate, salicylic acid valproic acid, and tolbutamide displace nimusulide from the plasma binding sites.
Nimesulide displaces methotrexate and frusemide from plasma proteins.
Nimesulide should be used ith caution along with warfarin since efficacy may be increased. Nimesulide may decrease efficacy of slow release theophylline prepns.
Concurrent use of levodopa with racemethionine may derease the therapeutic effects of levodopa.
Indication:
Pain and inflammation
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Nimesulide NSAID Jan 1995
2.Nimesulide 1.0%w/w 17-11-2009
+ Ethanol 31% w/w
Tropical solution
For the local application in releiving paining acute low backache,
Tendonitis, Tensosinovitis and sprains
3.Nimesulide 100mg ER 28-03-2008
+ Levocetrizine Hcl 5mg tablets
For symptomatic treatment of acute Rhinosimusitis
4.Nimesulide ER 200mg 18-05-2009
Addl.Indn.
Acute pain in orthopedic, ENT,Dental and Post operative pain
5.Nimesulide Injection 08-10-2004
100mg/ml
Veterinary
Veterinary use
6.Nimesulide injection 28-06-2004
75mg/ml
For short term treatment of post-operative pain
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Nimesulide 1% + 16-09-2005
Methyl salicylate 5% aerosol
Aerosol for local application in acute pain
2. Nimesulide 100mg + Approved for
Paracetamol 500mg tablets more than 4 years
Adverse Reaction:
Nausea, diarrhoea, vomiting, dizziness,rash somnolence, headache
Contra-Indications:
Nimesulide is contraindicated in active peptic ulcer and moderateto evere hepatic impairment . Nimesulide shuld be avoided in pregnant and lactating women
. Precautions-
To be used with caution in pts with renal impairment, heart failure, or cirrhosis, volume or salt depleted pts. elderely pts. salt depleted pts.
To be avoided in pregnant and lactaing women,metabolic acidosis, severe hepatic function impairment. Use racemethionine with caution.
Pharmacology/ Pharmacokinetics:
Pharmacology-
Nimesulide is a weak inhibitor o postagalndin synthesis.It apears to act at different stages of inflammatory reaction and the mechanism by which it exerts it action are many. It leads to inhibition of superoxide anion generation in vitro activated neutrophils,inhibitiion of histamine release from tissue mast cells and basophilis. It cause inhibion of platelet activating factor synthesis of metoproteinase thus preventing breakdown of osteoarthiritic human cartilage.
Pharmacokinetics-
After oral admin nimesulide is rapidly and alomost completely absorbed. It is highly bound to plasma proteins and is extensively metabolised in liver. The major metabolite is pharmacologically actve. The pharmacokinetis of raceethinine is not well known.
Manufacturer Details