Drugs that cause QT prolongatione.g quinidine, solatol, thioridazine, ziprasidone Potent or moderately potent CYP3A inhibitors e.g ketoconazole, other azole antifungals, dizepam, verapramil, macrolides, protease inhibitors, grape fruit juice Drugs metabolised by p-glycoproteins e.g digoxin, CYP2D6 e.g. tricyclic antidepressants CYP3A e.g simavastatin Inhibitors of CYP2D6 e.g. paroxetine, p-glycoprotein e.g. ritonovir, cyclosporine

Symptomatic treatment of patients with chronic stable angina

Dizziness, headache, nausea, constipation, Seizures, angioedema, tachycardia, tremors, numbness, haematuria, breathessness, Dry mouth, blurred vision, abdominal pain, weakness, tinnititus Bradycardia, hypotension. Elevation of serum creatinine level.

An acute attack of angina, QT prolongation, Ventricular tachycardia Liver impairment.

Drugs that cause QT prolongation eg. quinidine, salatol, thioridizine, Ziprasidone etc. Potent or moderately potent CYP3A inhibitors e.g ketoconazole, other azole antifungals, Diltiazem, verapramil, macrolides, protease inhibitors, grape fruit juice Severe renal impairment

Special precautions-

Monitor blood pressure QT inteterval, elderly, pregnancy

Lactation - not recommended

Dosage-

Swallow whole Intially 500mg twice daily, may increase to 1g daily Children- not recommended

Swallow whole tablet

Not recommended during pregnancy and lactation