Excess dietary tyramine, ciprofloxacin TCADs , tetracycline, pethidine, fluoxetine,fluvoxamine, Dextromethorphan, Sympathomimetics

Monotherapy, Headache.Flu-like syndrome. malaise, neck pain Depression, fever, angina,, dyspepsia, flatulence, leucopenia, Arthlagia, arthiritis, musculoskeletal pain, depression,vertigo, hallucinations Rhinitis,conjuntivitis,rash. Skin carcinoma, urinery urgency, Adjuntive therapy, Accidental injury,neck pain postural hypotension, GI upset, constipation, dry mouth, anorexia. Carpral tunnel syndrome, weight loss, dyskinesia, dystonia, Abnormal dreams, balance disorders, hallucinations.

Severe hepatic impairment. During or within 2 weeks of meperidone and MAOIs. Concomitant dextromethorphan. St.Johns wort. Cyclobenzaprine

Special Precautions-

Mild to moderate hepatic impairment. Monitor for melanoma Pregnancy. Lactation

Dosage-

0.5 to 1mg daily as required Patients below 18 years not recommended

Pharmacology-

Rasagiline is an irreversible monoamine oxidase (MAO) inhibitor indicated for treatment of idiopathic Parkinsons disease. Rasagiline inhibits MAO type B ( MAO- B) but addequate studies to establish whether Rasagiline is selective for Rasagiline for MAO-B in humans have not been conducted

Pharmacokinetics-

Studies have shown that Rasagiline irreversibly inhibits platelet MAO-B . The inhibition lasts for at least 1 week after the last dose. rasagiline is rapidly absorbed reaching peak plasma concentrations Cmax in approx. in 1 hour. The absolute bioavailbility is 36%

Food does affect the time to reach maximum concentration ( Tmax) although Cmax and exposure (AUC) are decreased by approx. by 60% and 20% respy. when taken with a high fat meal Because AUC is not significantly affected, rasagiline can be taken with or without food

Can be taken with or without food

 Pregnancy/ Lactation -Exercise caution