WALAMYCIN
Brand:
WALAMYCIN
Manufacturer:
WALLACE
Manufacturer Details
WALLACE
Compositions:
Colistin sulphate 12.5mg/ 5 ml suspension,
Colistin sulphate 25mg/5ml DS suspension,
|
Strength
|
Rate
|
Packing Style
|
|
12.5mg/5ml
|
33.00
|
30ml suspension
|
|
12.5mg/5ml
|
65.00
|
60ml suspension
|
|
25mg/5ml
|
84.60
|
3ml DS suspension
|
List of Related Indications:
List Of Drugs:
- Colistin sulphate ( * ) - Antidiarrheal- ( FDC- List )
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Interacting drugs - summary
Colistin sulphate+
Colistin sulpate and sodium colimethate + Pancuronium
Parentral/intraperitoneal administration of high doses of antibiotics produce neuromuscular block on its own. If these agents are used preoperatively or in conjunction with pancuronium during surgery, unexpected prolongation of neuromuscular block
is a possibility
Colistin and sodium colisthemate + Vecuronium
parentral/intraperitoneal admininistration of of high doses of certain antibiotics may intensify or produce neuromuscular blockade on their own. If these are newly introduced are used with vercuronium during surgery, consider the possibilty of unexpected prolongation of neuromuscular block
Colistin Colisthemate + Percuronium
Parentral/Peritoneal administration of high doses of cetain antibitotics may intensify or cause neuromuscular blockade on their own. If these or or newly introduced antibiotics are used with pipercuronium during surgery, consider prolongation of neuromuscular block, a possiblity.
Indication:
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Colistin sulphate 300000 IU 0.154gm+ Sep- 1969
Pectin 0.196gm +
Kaolin 2.625gm per 30ml suspn
2. Sterile powder of Colistin Sulphomethate Feb 1980
Sodium eq. to
1000000 units +
Dilucame 2mf per vial inj.
Diarrhoea in infants and children. Gastroenteritis due to shigella organisms..
Adverse Reaction:
Acute tubular necrosis,neurotoxicity.
The neuromuscular blockade is potentially fatal,when associated with use of curariform muscle relaxants,hypocalcaemia and aminoglycosides.
Superinfection,renal damage,
GI disturbances,visual & speech disturbances,dizziness,nausea, vomiting,confusion,peripheral neuropathy,respiratory insufficiency & muscle weakness.
Contra-Indications:
Hypersensitivity,Anura,Surgery.
Special precautions:
Preexisting renal impairment,curariform muscle relaxants.
Dosages/ Overdosage Etc:
Indications:
Diarrhoea in infants and children. Gastroenteritis due to shigella organisms..
Dosage:
Usual dosage is 5 to 15mg/kg/day given in 3 divided doses.
Assess renal function prior to initiation of therapy.
Other Information:
Tubular necrosis-
Drugs causing adverse reactions-
1. Ampotericin B
2. Aminoglycosides
3. Polymixin
4. Cephaloridine
5. Tetracycline
6. Colistin
7. Sulfonamides
8. Radioiodinated contrast media
9. Methoxyflurane
Pharmacology/ Pharmacokinetics:
Pharmacokinetics:
Colistin sulfate is not significantly absorbed into the systematic circulation.
Interaction with Food:
Not applicable
