Aspirin/paracetamol

Alcohol, corticosteroids, analgin, phenylbutazone may increae risk of GI ulceration.

Aspirin increases phenytoin levels.

May antogonise actions of uricosurics and spironolactone

May potentiate effects of anticogulants, methotrexate and oral hypoglycemics

Codeine- Alcohol, MAOIs CNS depressants, Phenytoin

Mild to moderate pain and fever

Aspirin/paracetamol

 GI disturbances, prolonged bleeding time, rhinitis, urticaria and epigastric discomfort Angioedema, salicylism, tinnitus, bronchospasm Gastric erosion, ulceration and bleeding Severe fatal exacerbation of airway obstruction in asthma

Reyes syndrome (children< 12 years ) Hepatoxicity CNS depression which may lead to coma. CV collapse and respiratory failure. Paroxymal bronchospasm and dyspnoea.

Codeine

Drowsiness, impaired reactions, constipation Nausea, dryness of the mouth, depedence, addition, blurred vision, Headache, dizziness, fatigue, Attention disturbances,

Respiratory depression in sensitive patients or if given in large doses.

Aspirin/Paracetamol

 Hypersentivity - (attacks of asthma, angioedema, urticaria or rhinitis ) Activre peptic ulceration Pregnancy (3rd trimester) Child < 12 years) Patients with haemophillia or haemorsrhagic disorders Gout. Severe renal or hepatic impairment Lactation.

Special precauions-

Histrory of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, Asthma or allergic disorders

Dehydrated patients,

Uncontrolled hypertension,

Impaired renal or hepatic function.

Elderly

Codeine

Liver disease, ventilatory failure Lactation

Special precautions-

Asthma, bronchitis, bronchiiectasis, hepatic or renal impairment

Children.

 Driving or operating machinery

Epliepsy

 Raised IOP, 

BPH, severe hypertension Cardiovascular disesase,

Thyrotoxicosis. Elderly Pregnancy

Indication-

Mild to moderate pain and fever

Dosage-

Aspirin Child- 80-100mg/kg daily in 5 or 6 divided dose Upto 130mg/kg/ daily in acute excerbations if necessary

Pain/inflamtion- adult- initial 2.4- to3.6 g/day in divided doses. Maintenance - 3.6 to 5.4 g /day . Monitor serum concentrates

Mild to moderate pain Adult- initial - 325-650mg repeated every 4- 6 hr acccording to response. Max 4g/day also be given

Contrindicated for use during pregnancy and lactation

Observe caution if use is needed.