Interacting drugs- summary

Magnesium salts +

• Aminoqinolones decr absorption and therapeutic effect of aminoquinolines decreased

• Magnesium salts with- Aminoquinolines decr absorption and therapeutic effect of aminoquinolines may be decreased

No adverse reports

Rheumatoid arthiritis. Sytemic lupus erythematosus Concurrent administration of drugs known to cause hemolysis

Indication

Treatment of Malaria Adults-

Dosage-

Day 1- 2 tablets of Chloroquine 500mg + 1 after 6 hours Day 2& 3 : 1 tablet of chloroquine 500mg + 1 capsule of butaquine 25mg Day 4,5 & 6: 1 capsule of bulaquine 25mg

Pharmacology:

Bulaquine has biological activity against the tissue schizoticides(radical cure) of P.vivax Theexact action is not fully understood. However, Bulaquine reportedly inhibits protein synthesis in prootozoa and indirectly inhibits polymerization of amino avids by the plasmoda.

Pharmacokinetics:

Serum concentration of Bulaquine and its metabolite, Primaquine determined by HPLC after a single oral dose showed an elimination half-life varying from 4.39 to 6.789 hrs. No studies have been conducted on children