AMICOR INJ
Manufacturer Details
SAMARTH PHARMA
Compositions:
Amrinone lactate 100mg/20ml inj,
Strength
|
Rate
|
Packing Style
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100mg/20ml
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0.00
|
Tab
|
List of Related Indications:
List Of Drugs:
- Amrinone lactate -Vasodilator
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Not reported.
Indication:
For short term management of CHF.
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref -IDMA publication)
Name of Drug Indication Date of Approval
Amrinone Lactate Inotropic agent May 1998
Adverse Reaction:
Thrombocytopenia. Nausea, vomiting, abdominal pain, anorexia, hepatotoxicity.
Should severe or debilitating GI effects occur, reduce dosage or discontinue the drug based on benefit-to-risk considerations.
Arrhythmias, hypotension.
Pericarditis, pleuritis and ascites, myosis with intersitial shadowing on chest X-ray and elevated sedimentation rates.
Hypoxemia and jaundice with oral amrione.
Fever, chest pain, burning at site of injection.
Contra-Indications:
Hypersens to amirinone or bisulfites.
Special precautions:
Do not use amrinone in patients with severe aortic or pulmonic valvular disease in lieu of surgical relief of the obstruction.
It may aggrevate outflow tract obstruction in hypertropic subaortic stenosis.
Arrhythmias,thrombocytopenia is more common in patients receiving prolonged therapy. Amrinone not recommended in acute mycardial infaction .
If acute marked alterations in liver enzymes occur together with clinical symptoms,discontinue amrione.
Monitor fluid and electrolyte changes and renal function during amrinone therapy.
Dosages/ Overdosage Etc:
Indications:
For short term management of CHF.
Dosage-
Initial therapy- 0.75mg/kg IV Bolus slowly over 2 to 3 minutes.Maintain infusion 5 to 10mcg/kg/min.
Do not exceed a total daily dose of 10mg/kg.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Amrinone is a positive inotropic agent with vasodilator activity,different in structure and mode of action from either digitalis glycosides or catecholamine. Its mechanism is not fully elucidated.
Pharmacokinetics:
Amrinone has a volume distribution of 1.2 litres/kg and a distribution half-life of about 4.6 minutes. It is 10 to 49% protein bound.
Interaction with Food:
Not available
Pregnancy and lactation:
Pregnancy:
Use during pregnancy only if the potential benefit justifies the potential risks to the fetus.
Lactation:
Excercise caution when administering to nursing women.