Mesalamine 400mg tabs,
List of Related Indications:
- Crohn's ileocolitis
- Ulcerative colitis
List Of Drugs:
- Mesalamine (5-amino salicylic acid)- @ Antidiarrheals-(2002)
Indication Type Description:
Dosages/ Overdosage Etc
Pregnancy and lactation
Should not be given with lactulose or other drugs which lower pH thereby preventing release of mesalazine.
NSAIDs . Coumarin anti-coagulants
Sulphonyl ureas, methotrexate probenicid
Azathioprine, Sulphinpyrazone, Sulphanolactone
Frusemide, rifampicin, glucocorticoids
Lab test abnormalities:
Elevated AST,ALT, alkaline phophatase, serum creatinine, BUN, amylase,lipase,GGTP, and LDH.
Ulcerative colitis Crohns colitis or ileocolitis
Sinusitis, interstital pneumonitis, asthma exacerabations, pulmonary infiltrates.
Pericarditis, myocarditis, vasodilations.
Anxiety, depression, somnolence, emotional lability,
Vertigo, nervousness, confusion, parathesia, tremor.
Anorexia, pancreatitis, gastritis
Hypersensitivity to mesalamine, salicylates
Salicylate hpersensitivity or renal sensitivity to sulphasalazine
Severe renal or hepatic impairment
Active peptic ulcer
Blood clotting anbormalities
Monitor renal function before and periodically during treatment
Maintain adequate hydration
Raised blood urea or proteinuria
Advice patients to report unusal bleeding
Dosages/ Overdosage Etc:
Chronic inflammatory bowel disease
Oral- tablets- 800mg 3 times daily for a total dose of 2.4g/day for 6 weeks
Capsules- 1g 4 times daily for a total dose of 4g for upto 8 weeks
Symptoms of salicylate toxicity may be possible. Such as tinnitus, vertigo, headache, confusion, drowsiness, sweating, hyperventilation, vomiting and diarrhea.
Severe intoxification with salicylates can lead to disruption of electrolyte balance and blood pH, hyperthermia and dehyratation.
1. Conventinal therapy of salicylate toxicity may be beneficial in the event of acute overdosage.
2. This includes prevention of further GI tract absorption by emesis and if necessary by gastric lavage
3. Correct fluid and electrolyte imbalance by the administration of appropriate IV therapy
4. Maintain adequate renal function.
1. If you miss a dose of this medicine, take it as soon as possible.
2. However, if it is almost time for next dose, skip the missed dose and go back to your regular dosing
3. Do not double doses.
REFER 5amino salicylic acid- ASA or Mesalamine
REFER- 5 amio salicylic 0r ASA or Mesalamine
1. Tablets- swallow tablets whole, do not break the outer coating, which is designed to remain intact to protect the active ingredient. In 2 to 3% of patients, intact or partially intact tablets are found in the stool. If this occurs, inform the physician
Sulfasalazine is split by bacterial action in the colon into sulfapyridine (SP) and messalamine
(5-ASA). It is thought that the mesalamine component is therapeutically active in ulcerative colitis.
The mechanism of action is unknown, but appears to be topical than systemic.
Mesalamine administered rectally as a suspension enema is poorly absorbed from the colon
and is excreted principally in the feces during subsequent bowel movements.
Pregnancy and lactation:
Use during only if needed.
Excercise caution while administering to a nursing woman.