Barbiturates, narcotics, antidiabetic agents,chlestyramine, colestipol, corticosteroids, ACTH, adrenaline, muscle relaxants lithium NSAIDs , potassium sparing diuretics rifampicin, fluconazole, indomethicin,

Hypertension not controlled by losartan or hydrochlothiazide

Dizziness, asthenia, vertigo, orthostatic effects, diarrhoea, rash, Gi- upset, muscle cramps,leg pain migraine, urticaria, pruritus eryhroderma, hyponatremia insomnia, raised LFTs , malaise acute myopia secondary angle closure glaucoma rarely, thabdomylosis, angioedema anaphylactic reactions vasculitis hepatitis, cough, anemia

Hepatic impairment Anuria moderate to severe renal impairment intravascular volume depletion, dialysis sulphonamide or penicillin allergy pregnancy lactation Special precaution- monitor serum electrolytes SLE, gout obstructive valvular disease cardiomyopathy aortic stenosis hepatic/ renal impairment severe cardiac insufficiency renal artery stenosis outflow obstruction

Hypertension not controlled by losartan or hydrochlothiazide

Dosage-

initially 1 tab daily increase to max, 2 tabs daily if reqd. not recommended for children

Use Contraindicated. Observe caution