Gonorrhoea
Meninigitis
Susceptible Infections
 

Contraindicated in patients with known allergy to penicillins and cephalosporins

Indications

Gonorrhoea
Meninigitis
Susceptible Infections

Dosage:  
Gonorrhoea -
Adults - 250mg as a single dose

Meningitis-
 Adult- 250mg as a single dose
Child- 125mg as a single dose

Susceptible Infections-
Adult- 1-2 g daily as a single dose given as deep IM inj or slow IV inj over 2-4  minutes or as
an infusion over at least 30 minutes, increased upto 4g daily in severe infections
Child- < 50g mg 25- 50mg/kg  once daily once daily increased to 80mg/kg in severe infections

Doses > 50mg/kg should be given as IV infusion
IV infusion in neonates should be given over 60 minutes
Max dose neonates-  50mg/kg/day 

Pharmacology

The bacterial action of ceftriaxone + sulbatum is due to the the ceftriaxone component and the ability of ceftriaxone to interefere with the biosynthesis of the peptidoglycan component of the bacterial cell wall by binding to gram and negative bacteria.

Sulbactum is broader spectrum beta-lactamase inhibitor than cluvanic acid. Sulbactum does not induce chromosomal beta-lactmases like clavulinic acid nor does it select for derepressed beta- lactamase producing bacteria

Pharmacokinetics

Ceftriaxone + sulbactum can be administered IM or IV. Folllowing intamuscularly administration peak serum concentration of ceftriaxone + sulbactum are seen between 15 minutes to 2 hrs.

Ceftriaxone is not metabolised in the body and is eliminated unchanged via urine and bile. Within 48 hrs 40-50% of parentrally administred dose is excreted into urine as active drug.